Document Detail


Synthesis of sulfated pectins and their anticoagulant activity.
MedLine Citation:
PMID:  20636268     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The following pectins were sulfated: bergenan BC (the pectin of Bergenia crassifolia L), lemnan LM (the pectin of Lemna minor L), and galacturonan as a backbone of pectins. Pyridine monomethyl sulfate, pyridine sulfotrioxide, and chlorosulfonic acid were used as reagents for sulfation. Chlorosulfonic acid proved to be the optimal reagent for sulfation of galacturonan and other pectins. Galacturonan and pectin derivatives with different degrees of sulfation were synthesized and their anticoagulant activities were shown to depend on the quantity of sulfate groups in the pectin macromolecules.
Authors:
F V Vityazev; V V Golovchenko; O A Patova; N N Drozd; V A Makarov; A S Shashkov; Yu S Ovodov
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemistry. Biokhimii͡a     Volume:  75     ISSN:  1608-3040     ISO Abbreviation:  Biochemistry Mosc.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-07-19     Completed Date:  2010-10-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376536     Medline TA:  Biochemistry (Mosc)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  759-68     Citation Subset:  IM    
Affiliation:
Institute of Physiology, Komi Science Center, Syktyvkar, Russia.
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MeSH Terms
Descriptor/Qualifier:
Anticoagulants / chemistry*,  pharmacology
Magnetic Resonance Spectroscopy
Pectins / chemical synthesis,  chemistry*
Spectrophotometry, Infrared
Sulfonic Acids / chemistry
Sulfur / chemistry*
Chemical
Reg. No./Substance:
0/Anticoagulants; 0/Pectins; 0/Sulfonic Acids; 0/bergenan BC; 0/lemnan; 7704-34-9/Sulfur; 7790-94-5/chlorosulfonic acid; 9046-38-2/polygalacturonic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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