| Synthesis of sulfated pectins and their anticoagulant activity. | |
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MedLine Citation:
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PMID: 20636268 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The following pectins were sulfated: bergenan BC (the pectin of Bergenia crassifolia L), lemnan LM (the pectin of Lemna minor L), and galacturonan as a backbone of pectins. Pyridine monomethyl sulfate, pyridine sulfotrioxide, and chlorosulfonic acid were used as reagents for sulfation. Chlorosulfonic acid proved to be the optimal reagent for sulfation of galacturonan and other pectins. Galacturonan and pectin derivatives with different degrees of sulfation were synthesized and their anticoagulant activities were shown to depend on the quantity of sulfate groups in the pectin macromolecules. |
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Authors:
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F V Vityazev; V V Golovchenko; O A Patova; N N Drozd; V A Makarov; A S Shashkov; Yu S Ovodov |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biochemistry. Biokhimii͡a Volume: 75 ISSN: 1608-3040 ISO Abbreviation: Biochemistry Mosc. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-07-19 Completed Date: 2010-10-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376536 Medline TA: Biochemistry (Mosc) Country: United States |
Other Details:
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Languages: eng Pagination: 759-68 Citation Subset: IM |
Affiliation:
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Institute of Physiology, Komi Science Center, Syktyvkar, Russia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anticoagulants
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chemistry*,
pharmacology Magnetic Resonance Spectroscopy Pectins / chemical synthesis, chemistry* Spectrophotometry, Infrared Sulfonic Acids / chemistry Sulfur / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 0/Pectins; 0/Sulfonic Acids; 0/bergenan BC; 0/lemnan; 7704-34-9/Sulfur; 7790-94-5/chlorosulfonic acid; 9046-38-2/polygalacturonic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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