Document Detail


Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: Part 1.
MedLine Citation:
PMID:  23369538     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In an effort to develop potent and selective inhibitors toward ACAT2, structure-activity relationship studies were carried out using derivatives based on pyripyropene A (PPPA, 1). We have successfully developed novel PPPA derivatives with a 7-O-substituted benzoyl substituent that significantly exhibit more potent ACAT2 inhibitory activity and higher ACAT2 isozyme selectivity than 1.
Authors:
Masaki Ohtawa; Hiroyuki Yamazaki; Satoshi Ohte; Daisuke Matsuda; Taichi Ohshiro; Lawrence L Rudel; Satoshi Omura; Hiroshi Tomoda; Tohru Nagamitsu
Related Documents :
23740878 - α-l-fucosidase inhibition by pyrrolidine-ferrocene hybrids: rationalization of ligand-...
23892508 - Synthesis and biological evaluation of truncated α-tubulin-binding pironetin analogues...
23480178 - Structural and kinetic study of an internal substrate binding site of dehaloperoxidase-...
23515568 - Research on the regulation of the spatial structure of acetylcholinesterase tetramer wi...
1783608 - Cysteine protease inhibitor in egg of chum salmon.
8520518 - Intracytoplasmic sequences involved in the biological properties of low-affinity recept...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-9
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  -     ISSN:  1464-3405     ISO Abbreviation:  Bioorg. Med. Chem. Lett.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-2-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 Elsevier Ltd. All rights reserved.
Affiliation:
Graduate School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Syntheses of lipophilic chalcones and their conformationally restricted analogues as antitubercular ...
Next Document:  Rapid microwave-enhanced synthesis of C5-alkynyl pyranonucleosides as novel cytotoxic antitumor agen...