Document Detail


Synthesis and structure-activity relationship of benzetimide derivatives as human CXCR3 antagonists.
MedLine Citation:
PMID:  18922694     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The synthesis and evaluation of benzetimide derivatives showing potent CXCR3 antagonism are described. Optimization of the screening hits led to the identification of more potent CXCR3 antagonists devoid of anti-cholinergic activity and identification of the key pharmacophore moieties of the series.
Authors:
Jean-Pierre Bongartz; Mieke Buntinx; Erwin Coesemans; Bart Hermans; Guy Van Lommen; Jean Van Wauwe
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Publication Detail:
Type:  Journal Article     Date:  2008-07-31
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  18     ISSN:  1464-3405     ISO Abbreviation:  Bioorg. Med. Chem. Lett.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2009-10-30     Completed Date:  2009-12-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  England    
Other Details:
Languages:  eng     Pagination:  5819-23     Citation Subset:  IM    
Affiliation:
Johnson & Johnson PRD, RED EU, Turnhoutseweg 30, B-2340 Beerse, Belgium. jbongart@its.inj.com
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MeSH Terms
Descriptor/Qualifier:
Dexetimide / chemistry,  pharmacology*
Humans
Receptors, CXCR3 / antagonists & inhibitors*
Structure-Activity Relationship
Chemical
Reg. No./Substance:
0/CXCR3 protein, human; 0/Receptors, CXCR3; 21888-98-2/Dexetimide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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