Document Detail

Synthesis and structure-activity relationship of benzetimide derivatives as human CXCR3 antagonists.
MedLine Citation:
PMID:  18922694     Owner:  NLM     Status:  MEDLINE    
The synthesis and evaluation of benzetimide derivatives showing potent CXCR3 antagonism are described. Optimization of the screening hits led to the identification of more potent CXCR3 antagonists devoid of anti-cholinergic activity and identification of the key pharmacophore moieties of the series.
Jean-Pierre Bongartz; Mieke Buntinx; Erwin Coesemans; Bart Hermans; Guy Van Lommen; Jean Van Wauwe
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Publication Detail:
Type:  Journal Article     Date:  2008-07-31
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  18     ISSN:  1464-3405     ISO Abbreviation:  Bioorg. Med. Chem. Lett.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2009-10-30     Completed Date:  2009-12-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  England    
Other Details:
Languages:  eng     Pagination:  5819-23     Citation Subset:  IM    
Johnson & Johnson PRD, RED EU, Turnhoutseweg 30, B-2340 Beerse, Belgium.
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MeSH Terms
Dexetimide / chemistry,  pharmacology*
Receptors, CXCR3 / antagonists & inhibitors*
Structure-Activity Relationship
Reg. No./Substance:
0/CXCR3 protein, human; 0/Receptors, CXCR3; 21888-98-2/Dexetimide

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