| Synthesis and structural analysis of 6-aminobicyclo[2.2.1]heptane-2-carboxylic acid as a conformationally constrained gamma-turn mimic. | |
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MedLine Citation:
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PMID: 18991775 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An efficient asymmetric synthesis of 6-aminobicyclo[2.2.1]heptane-2-carboxylic acid as a novel gamma-turn mimic has been achieved. Structural analysis of the gamma-amino acid derivative was carried out using (1)H NMR spectroscopy and intramolecular hydrogen bonding between side chain amides confirmed the turn structure, which had been predicted by Ab initio computational study. |
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Authors:
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Jin-Seong Park; Kyoung Rak Kim; Hye Young Nam; Chang-Eun Yeom; Chieyeon Chough; Soon Ho Kwon; Seonggu Ro; Dong-Kyu Shin; B Moon Kim |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Protein and peptide letters Volume: 15 ISSN: 0929-8665 ISO Abbreviation: Protein Pept. Lett. Publication Date: 2008 |
Date Detail:
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Created Date: 2008-11-10 Completed Date: 2008-12-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9441434 Medline TA: Protein Pept Lett Country: Netherlands |
Other Details:
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Languages: eng Pagination: 980-4 Citation Subset: IM |
Affiliation:
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Department of Chemistry, College of Natural Sciences, Seoul National University, Seoul, 151-747, South Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids, Cyclic
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chemical synthesis*,
chemistry* Bicyclo Compounds / chemical synthesis*, chemistry* Heptanes / chemistry Hydrogen Bonding Magnetic Resonance Spectroscopy Models, Molecular Molecular Mimicry Molecular Structure Norbornanes Protein Structure, Secondary |
| Chemical | |
Reg. No./Substance:
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0/6-aminobicyclo(2.2.1)heptane-2-carboxylic acid; 0/Amino Acids, Cyclic; 0/Bicyclo Compounds; 0/Heptanes; 0/Norbornanes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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