Document Detail


Synthesis of some new hydrazide-hydrazones, thiosemicarbazides, thiadiazoles, triazoles and their derivatives as possible antimicrobials.
MedLine Citation:
PMID:  2381974     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The title compounds were prepared by reacting [(4,5-diphenyl-1H-imidazol-2-yl)thio]acetic acid hydrazides 6 and 7 with aromatic aldehydes to give the corresponding hydrazones 6a-m and 7a-d or with isothiocyanates to afford the corresponding thiosemicarbazides 8a-c and 9. 8a-c and 9 were cyclized into triazoline-5-thiones 10a-c and 11 in the presence of sodium hydroxide or into 1,3,4-thiadiazoles 14a-c and 15 in the presence of sulfuric acid. On the other hand, 10c and 11 were also reacted with alkyl halides to obtain their thioether derivatives, 12a,b and 13. All the synthesized compounds were characterized by their elementary analysis and by using UV, IR, NMR and mass spectrometry. 6b, c, f, h-k, m, 7, 7d, 8c, 9, 10c, 11, 12a-b, 13, 14 and 15 were tested for antimicrobial activity, but no significant activity was observed.
Authors:
A Gürsoy; S Demirayak; Z Cesur; J Reisch; G Otük
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Die Pharmazie     Volume:  45     ISSN:  0031-7144     ISO Abbreviation:  Pharmazie     Publication Date:  1990 Apr 
Date Detail:
Created Date:  1990-09-13     Completed Date:  1990-09-13     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9800766     Medline TA:  Pharmazie     Country:  GERMANY, EAST    
Other Details:
Languages:  eng     Pagination:  246-50     Citation Subset:  IM    
Affiliation:
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Istanbul, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Anti-Bacterial Agents
Anti-Infective Agents / chemical synthesis*,  pharmacology
Bacteria / drug effects
Chemical Phenomena
Chemistry
Fungi / drug effects
Hydrazones / chemical synthesis*,  pharmacology
Microbial Sensitivity Tests
Thiadiazoles / chemical synthesis*,  pharmacology
Thiosemicarbazones / chemical synthesis*,  pharmacology
Triazoles / chemical synthesis*,  pharmacology
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Anti-Infective Agents; 0/Hydrazones; 0/Thiadiazoles; 0/Thiosemicarbazones; 0/Triazoles

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