Document Detail

Synthesis of some new hydrazide-hydrazones, thiosemicarbazides, thiadiazoles, triazoles and their derivatives as possible antimicrobials.
MedLine Citation:
PMID:  2381974     Owner:  NLM     Status:  MEDLINE    
The title compounds were prepared by reacting [(4,5-diphenyl-1H-imidazol-2-yl)thio]acetic acid hydrazides 6 and 7 with aromatic aldehydes to give the corresponding hydrazones 6a-m and 7a-d or with isothiocyanates to afford the corresponding thiosemicarbazides 8a-c and 9. 8a-c and 9 were cyclized into triazoline-5-thiones 10a-c and 11 in the presence of sodium hydroxide or into 1,3,4-thiadiazoles 14a-c and 15 in the presence of sulfuric acid. On the other hand, 10c and 11 were also reacted with alkyl halides to obtain their thioether derivatives, 12a,b and 13. All the synthesized compounds were characterized by their elementary analysis and by using UV, IR, NMR and mass spectrometry. 6b, c, f, h-k, m, 7, 7d, 8c, 9, 10c, 11, 12a-b, 13, 14 and 15 were tested for antimicrobial activity, but no significant activity was observed.
A Gürsoy; S Demirayak; Z Cesur; J Reisch; G Otük
Related Documents :
7952034 - Retention behaviour of some barbituric acid derivatives on a polyethylene-coated silica...
8968394 - Biosynthesis of marcfortine a.
19104484 - Caffeic acid derivatives from eupatorium perfoliatum l.
20835454 - Rhodium-catalysed conjugate addition of arylboronic acids to enantiopure dehydroamino a...
8083564 - Arachidonic acid stimulates corneal epithelial migration.
10699844 - Volumetric properties of nucleic acids.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Die Pharmazie     Volume:  45     ISSN:  0031-7144     ISO Abbreviation:  Pharmazie     Publication Date:  1990 Apr 
Date Detail:
Created Date:  1990-09-13     Completed Date:  1990-09-13     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9800766     Medline TA:  Pharmazie     Country:  GERMANY, EAST    
Other Details:
Languages:  eng     Pagination:  246-50     Citation Subset:  IM    
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Istanbul, Turkey.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anti-Bacterial Agents
Anti-Infective Agents / chemical synthesis*,  pharmacology
Bacteria / drug effects
Chemical Phenomena
Fungi / drug effects
Hydrazones / chemical synthesis*,  pharmacology
Microbial Sensitivity Tests
Thiadiazoles / chemical synthesis*,  pharmacology
Thiosemicarbazones / chemical synthesis*,  pharmacology
Triazoles / chemical synthesis*,  pharmacology
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Anti-Infective Agents; 0/Hydrazones; 0/Thiadiazoles; 0/Thiosemicarbazones; 0/Triazoles

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Potential cardiotonics. 7. Synthesis and cardiovascular effects of 5-(4-pyridinyl)-, 6-methyl-4-(4-p...
Next Document:  Relation of structure, gas chromatographic retention data and local anesthetic activity and toxicity...