| Synthesis of some new hydrazide-hydrazones, thiosemicarbazides, thiadiazoles, triazoles and their derivatives as possible antimicrobials. | |
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MedLine Citation:
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PMID: 2381974 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The title compounds were prepared by reacting [(4,5-diphenyl-1H-imidazol-2-yl)thio]acetic acid hydrazides 6 and 7 with aromatic aldehydes to give the corresponding hydrazones 6a-m and 7a-d or with isothiocyanates to afford the corresponding thiosemicarbazides 8a-c and 9. 8a-c and 9 were cyclized into triazoline-5-thiones 10a-c and 11 in the presence of sodium hydroxide or into 1,3,4-thiadiazoles 14a-c and 15 in the presence of sulfuric acid. On the other hand, 10c and 11 were also reacted with alkyl halides to obtain their thioether derivatives, 12a,b and 13. All the synthesized compounds were characterized by their elementary analysis and by using UV, IR, NMR and mass spectrometry. 6b, c, f, h-k, m, 7, 7d, 8c, 9, 10c, 11, 12a-b, 13, 14 and 15 were tested for antimicrobial activity, but no significant activity was observed. |
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Authors:
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A Gürsoy; S Demirayak; Z Cesur; J Reisch; G Otük |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Die Pharmazie Volume: 45 ISSN: 0031-7144 ISO Abbreviation: Pharmazie Publication Date: 1990 Apr |
Date Detail:
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Created Date: 1990-09-13 Completed Date: 1990-09-13 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9800766 Medline TA: Pharmazie Country: GERMANY, EAST |
Other Details:
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Languages: eng Pagination: 246-50 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Istanbul, Turkey. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Bacterial Agents Anti-Infective Agents / chemical synthesis*, pharmacology Bacteria / drug effects Chemical Phenomena Chemistry Fungi / drug effects Hydrazones / chemical synthesis*, pharmacology Microbial Sensitivity Tests Thiadiazoles / chemical synthesis*, pharmacology Thiosemicarbazones / chemical synthesis*, pharmacology Triazoles / chemical synthesis*, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Anti-Infective Agents; 0/Hydrazones; 0/Thiadiazoles; 0/Thiosemicarbazones; 0/Triazoles |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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