Document Detail


Synthesis of some new 4,5-substituted-4H-1,2,4-triazole-3-thiol derivatives.
MedLine Citation:
PMID:  18007424     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this study appropriate hydrazide compounds, furan-2-carboxylic acid hydrazide (1) and phenylacetic acid hydrazide (2) were converted into 1,4-substituted thiosemicarbazides 4a-e and 5a-e and 4-amino-5-(furan-2-yl or benzyl)-4H-1,2,4-triazole-3-thiols 7 and 10. The 1,4-substituted thiosemicarbazides were then converted into 5-(furan-2-yl or benzyl)-4-(aryl)-4H-1,2,4-triazole-3-thiols 8a-e and 9a-e. In addition, the azomethines 11a-d and 12a-d were prepared from the corresponding arylaldehydes and the 4-amino-5-(furan-2-yl or benzyl)-4H-1,2,4-triazole-3-thiols 7 and 10. The structures of all the synthesized compounds were confirmed by elemental analyses, IR, (1)H-NMR and(13) C-NMR spectra.
Authors:
A Cansiz; M Koparir; A Demirdağ
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Publication Detail:
Type:  Journal Article     Date:  2004-03-31
Journal Detail:
Title:  Molecules (Basel, Switzerland)     Volume:  9     ISSN:  1420-3049     ISO Abbreviation:  Molecules     Publication Date:  2004  
Date Detail:
Created Date:  2007-11-16     Completed Date:  2008-03-24     Revised Date:  2009-10-27    
Medline Journal Info:
Nlm Unique ID:  100964009     Medline TA:  Molecules     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  204-12     Citation Subset:  IM    
Affiliation:
Department of Chemistry, Faculty of Science, Firat University, 23119, Elaziğ, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Anti-Infective Agents / chemistry
Furans / chemistry
Herbicides / chemistry
Hydrazines / chemistry
Molecular Structure
Phenylacetates / chemistry
Sulfhydryl Compounds* / chemical synthesis,  chemistry
Triazoles* / chemical synthesis,  chemistry
Chemical
Reg. No./Substance:
0/Anti-Infective Agents; 0/Furans; 0/Herbicides; 0/Hydrazines; 0/Phenylacetates; 0/Sulfhydryl Compounds; 0/Triazoles; 103-82-2/phenylacetic acid; 88-14-2/2-furoic acid

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