Document Detail


Synthesis of some 3- and 4-substituted 1,5-diphenylpyrrolidine-2,4-diones as potential antimicrobial and antineoplastic agents. Reactions with tetramic acid, Part 5.
MedLine Citation:
PMID:  12227189     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The condensation of 1,5-diphenylpyrrolidine-2,4-dione (1) with the carboxyl compounds 2a-f afforded the corresponding 3-arylidene-1,5-diphenylpyrrolidine-2,4-diones 3a-f. Reaction of the parent compound 1 with isatin (4) yielded the condensation product 5 in an acidic medium, whereas compound 6 was obtained in an alkaline medium. The condensation of the primary amines 7a-f with compound 1 afforded the corresponding 4-substituted amino-1,5-diphenyl-delta 3-pyrrolin-2-ones 8a-f. All the compounds synthesized were screened for their antimicrobial activity, and four compounds were selected for screening for their antineoplastic activity. The compounds tested showed both antimicrobial and antineoplastic activities.
Authors:
M N S Saudi; M M A el Semary; G el Sawaf
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Die Pharmazie     Volume:  57     ISSN:  0031-7144     ISO Abbreviation:  Pharmazie     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-09-13     Completed Date:  2002-10-08     Revised Date:  2007-01-29    
Medline Journal Info:
Nlm Unique ID:  9800766     Medline TA:  Pharmazie     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  519-22     Citation Subset:  IM    
Affiliation:
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Egypt.
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MeSH Terms
Descriptor/Qualifier:
Anti-Bacterial Agents / chemical synthesis,  chemistry*
Antineoplastic Agents / chemical synthesis,  chemistry*
Bacteria / drug effects
Drug Screening Assays, Antitumor
Humans
Indicators and Reagents
Microbial Sensitivity Tests
Pyrrolidines / chemical synthesis,  chemistry*
Pyrrolidinones / chemistry*
Quality Control
Spectrophotometry, Infrared
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Antineoplastic Agents; 0/Indicators and Reagents; 0/Pyrrolidines; 0/Pyrrolidinones; 503-83-3/tetramic acid

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