Document Detail

Synthesis of some 3- and 4-substituted 1,5-diphenylpyrrolidine-2,4-diones as potential antimicrobial and antineoplastic agents. Reactions with tetramic acid, Part 5.
MedLine Citation:
PMID:  12227189     Owner:  NLM     Status:  MEDLINE    
The condensation of 1,5-diphenylpyrrolidine-2,4-dione (1) with the carboxyl compounds 2a-f afforded the corresponding 3-arylidene-1,5-diphenylpyrrolidine-2,4-diones 3a-f. Reaction of the parent compound 1 with isatin (4) yielded the condensation product 5 in an acidic medium, whereas compound 6 was obtained in an alkaline medium. The condensation of the primary amines 7a-f with compound 1 afforded the corresponding 4-substituted amino-1,5-diphenyl-delta 3-pyrrolin-2-ones 8a-f. All the compounds synthesized were screened for their antimicrobial activity, and four compounds were selected for screening for their antineoplastic activity. The compounds tested showed both antimicrobial and antineoplastic activities.
M N S Saudi; M M A el Semary; G el Sawaf
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Die Pharmazie     Volume:  57     ISSN:  0031-7144     ISO Abbreviation:  Pharmazie     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-09-13     Completed Date:  2002-10-08     Revised Date:  2007-01-29    
Medline Journal Info:
Nlm Unique ID:  9800766     Medline TA:  Pharmazie     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  519-22     Citation Subset:  IM    
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Egypt.
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MeSH Terms
Anti-Bacterial Agents / chemical synthesis,  chemistry*
Antineoplastic Agents / chemical synthesis,  chemistry*
Bacteria / drug effects
Drug Screening Assays, Antitumor
Indicators and Reagents
Microbial Sensitivity Tests
Pyrrolidines / chemical synthesis,  chemistry*
Pyrrolidinones / chemistry*
Quality Control
Spectrophotometry, Infrared
Tumor Cells, Cultured
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Antineoplastic Agents; 0/Indicators and Reagents; 0/Pyrrolidines; 0/Pyrrolidinones; 503-83-3/tetramic acid

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