Document Detail

Synthesis of shrimp red pigment-concentrating hormone analogs and their biological activity in locusts.
MedLine Citation:
PMID:  6698714     Owner:  NLM     Status:  MEDLINE    
Two analogs of the red pigment-concentrating hormone (RPCH) have been synthesized by the solid-phase method: [Thr6]-RPCH (I) and [Tyr4, Thr6]-RCPH (II). Analog I has the same amino acid composition as the second adipokinetic hormone (AKH-II) isolated from locust corpora cardiaca. Bioassay for lipid-mobilizing activity in adult male locusts gave the following increases in hemolymph lipid content: AKH-I, 3.5; I, 2.4; II, 2.9. The biological response shown by I lends support to the conclusion that its sequence is that of the presumptive AKH-II. Replacement of Phe in position 4 by Tyr does not reduce the adipokinetic response.
D Yamashiro; S W Applebaum; C H Li
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  International journal of peptide and protein research     Volume:  23     ISSN:  0367-8377     ISO Abbreviation:  Int. J. Pept. Protein Res.     Publication Date:  1984 Jan 
Date Detail:
Created Date:  1984-04-13     Completed Date:  1984-04-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0330420     Medline TA:  Int J Pept Protein Res     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  39-41     Citation Subset:  IM    
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MeSH Terms
Biological Assay
Decapoda (Crustacea) / physiology*
Grasshoppers / physiology*
Hemolymph / drug effects,  metabolism
Indicators and Reagents
Invertebrate Hormones / chemical synthesis*
Lipid Metabolism
Grant Support
Reg. No./Substance:
0/Indicators and Reagents; 0/Invertebrate Hormones

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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