Document Detail

Synthesis of serotonin in traumatized rat brain.
MedLine Citation:
PMID:  7861164     Owner:  NLM     Status:  MEDLINE    
Previous studies have demonstrated that focal freezing lesions in rats cause a widespread decrease of cortical glucose use in the lesioned hemisphere and this was interpreted as a reflection of depression of cortical activity. The serotonergic neurotransmitter system was implicated in these alterations when it was shown that (1) cortical serotonin metabolism was increased widely in focally injured brain and (2) inhibition of serotonin synthesis prevented the development of cortical hypometabolism. In the present studies we applied an autoradiographic method that uses the accumulation of the 14C-labeled analogue of serotonin alpha-methylserotonin to assess changes in the rate of serotonin synthesis in injured brain. The results confirmed that 3 days after the lesion was made, at the time of greatest depression of glucose use, serotonin synthesis was significantly increased in cortical areas throughout the injured hemisphere. The increase was also seen in the dorsal hippocampus and area CA3, as well as in the medial geniculate and dorsal raphe, but not in any other subcortical structures including median raphe. Present results suggest that the functional changes in the cortex of the lesioned hemisphere are associated with an increased rate of serotonin synthesis mediated by activation of the dorsal raphe. We also documented by alpha-[14C]aminoisobutyric acid autoradiography that there was increased permeability of the blood-brain barrier, but this was restricted to the rim of the lesion.
K Tsuiki; A Takada; S Nagahiro; M Grdisa; M Diksic; H M Pappius
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of neurochemistry     Volume:  64     ISSN:  0022-3042     ISO Abbreviation:  J. Neurochem.     Publication Date:  1995 Mar 
Date Detail:
Created Date:  1995-03-17     Completed Date:  1995-03-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  2985190R     Medline TA:  J Neurochem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1319-25     Citation Subset:  IM    
Cone Laboratory for Neurosurgical Research, Montreal Neurological Institute and Hospital, Quebec, Canada.
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MeSH Terms
Brain / metabolism*
Brain Injuries / metabolism*
Cerebral Cortex / metabolism*
Rats, Sprague-Dawley
Serotonin / biosynthesis*
Time Factors
Tryptophan / analogs & derivatives,  metabolism
Wounds and Injuries / metabolism
Grant Support
Reg. No./Substance:
13510-08-2/alpha-methyltryptophan; 50-67-9/Serotonin; 73-22-3/Tryptophan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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