| Synthesis of selenophene derivatives as novel CHK1 inhibitors. | |
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MedLine Citation:
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PMID: 20674356 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A series of selenophene derivatives 3 were synthesized as potential CHK1 inhibitors. The effects of substitution on the 4'- or 5'-position of selenophene moiety and shifting the hydroxyl group position on C6- phenolic ring of oxindole were explored. This study led to the discovery of the most potent CHK1 inhibitors 29-33 and 39-43, which had IC(50) values in the subnanomolar range. |
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Authors:
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Pao-Chiung Hong; Li-Jung Chen; Tzu-Yun Lai; Huei-Yu Yang; Shih-Jan Chiang; Yann-Yu Lu; Ping-Kuei Tsai; Hung-Yi Hsu; Win-Yin Wei; Chu-Bin Liao |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-13 |
Journal Detail:
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Title: Bioorganic & medicinal chemistry letters Volume: 20 ISSN: 1464-3405 ISO Abbreviation: Bioorg. Med. Chem. Lett. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-16 Completed Date: 2010-12-06 Revised Date: 2011-11-02 |
Medline Journal Info:
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Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: England |
Other Details:
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Languages: eng Pagination: 5065-8 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Development Center for Biotechnology, Xizhi City, Taipei County, Taiwan. pchong@mail.dcb.org.tw |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Protein Kinase Inhibitors
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chemical synthesis*,
pharmacology Protein Kinases / drug effects* Selenium Compounds / chemical synthesis*, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Protein Kinase Inhibitors; 0/Selenium Compounds; EC 2.7.-/Protein Kinases; EC 2.7.11.1/Checkpoint kinase 1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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