| Synthesis of segmented poly(ether urethane)s and poly(ether urethane urea)s incorporating various side-chain or backbone functionalities. | |
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MedLine Citation:
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PMID: 15794490 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A series of linear and branched functionalized high-molecular-weight segmented poly (ether urethane)s and poly(ether urethane urea)s were prepared by chain-extending isocyanate pre-polymers based on poly(tetramethylene oxide) with molecular weight 1000 and 4,4'-diphenylmethane diisocyanate. Different functional groups were incorporated within the polymer backbone or on side-chains by using several chain extenders during the synthesis: glycerol, 2,2-bis (hydroxymethyl) propionic acid, 1H, 1H,2H,3H,3H-perfluoroundecane-1,2-diol, 1H,1H,8H,8H-dodecanefluoro-1,8-octanediol, 1,3-diamino-2-hydroxypropane and 3,5-diaminobenzoic acid, using the method of gradual approach to stoichiometry. In some cases, pendant functional groups were used as reactive sites for the further attachment of side groups. Polymers were characterized using 1H-NMR and FT-IR spectroscopies and GPC in conjunction with chemical structural confirmation by a model compound comparison study of 4,4'-diphenylmethane diisocyanate or trifluoro-p-tolyl isocyanate reacted with 1,3-diamino-2-hydroxypropane and 1,4-butanediol. |
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Authors:
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Felix I Simonovsky; Stephen C Porter; Buddy D Ratner |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of biomaterials science. Polymer edition Volume: 16 ISSN: 0920-5063 ISO Abbreviation: J Biomater Sci Polym Ed Publication Date: 2005 |
Date Detail:
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Created Date: 2005-03-29 Completed Date: 2006-01-11 Revised Date: 2008-02-20 |
Medline Journal Info:
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Nlm Unique ID: 9007393 Medline TA: J Biomater Sci Polym Ed Country: Netherlands |
Other Details:
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Languages: eng Pagination: 267-84 Citation Subset: IM |
Affiliation:
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Department of Bioengineering, University of Washington, P.O. Box 351720, Seattle, WA 98195-1720, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Chromatography, Gel Magnetic Resonance Spectroscopy Polyurethanes / chemical synthesis*, chemistry Spectroscopy, Fourier Transform Infrared |
| Grant Support | |
ID/Acronym/Agency:
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HL25951/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Polyurethanes; 0/poly(etherurethane urea); 0/polyetherurethane |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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