| Synthesis and secretion of some plasma proteins by tissue slices of Morris hepatoma 7777 and liver from control and turpentine-injected rats. | |
| | |
MedLine Citation:
|
PMID: 6199267 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Slices of Morris hepatoma 7777 or rat liver isolated from control or turpentine-injected rats were incubated for 2 h with 14C-leucine. Radioactivities incorporated into albumin, alpha-fetoprotein, fibrinogen, alpha 1-AP-globulin, haptoglobin and alpha 1-acid glycoprotein were determined after the proteins had been isolated from the incubation medium or tissue homogenate by immunoprecipitation with monospecific antisera. It was found that hepatoma synthesizes fibrinogen, alpha 1-AP-globulin and alpha 1-acid glycoprotein in the amounts comparable to rat liver, whereas formation of albumin and haptoglobin is reduced 5- to 10-fold. Local inflammation elicited by injection of turpentine to tissue donors increased formation of acute-phase protein in liver slices but had no effect on synthesis of these proteins in preparations of Morris hepatoma, although certain ultrastructural changes in the Golgi complex were observed not only in the liver but also in the tumour. |
| | |
Authors:
|
A Koj; A Dubin; H Kasperczyk; F Kaczmarski; D Stankiewicz |
Related Documents
:
|
9625597 - Suppression of hypercholesterolemia in hepatoma-bearing rats by cabbage extract and its... 2888657 - Characterization of gamma-glutamyltransferase from neoplastic and non-neoplastic liver ... 184007 - Beta-glucuronidase isozyme patterns of experimental hepatomas of rats. 7248957 - Salvage of circulating pyrimidine nucleosides in the rat. 6732927 - Role of olfactory bulbectomy and dsp4 treatment in avoidance learning in the rat. 19000367 - Effects of intestinal constituents and lipids on intestinal formation and pharmacokinet... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Folia histochemica et cytochemica Volume: 21 ISSN: 0015-5586 ISO Abbreviation: Folia Histochem Cytochem (Krakow) Publication Date: 1983 |
Date Detail:
|
Created Date: 1984-04-06 Completed Date: 1984-04-06 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 2984760R Medline TA: Folia Histochem Cytochem (Krakow) Country: POLAND |
Other Details:
|
Languages: eng Pagination: 211-8 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Proteins / biosynthesis* Liver / drug effects, metabolism Liver Neoplasms, Experimental / metabolism* Neoplasm Proteins / biosynthesis* Rats Serum Globulins / biosynthesis Turpentine / pharmacology alpha-Fetoproteins / biosynthesis alpha-Macroglobulins / biosynthesis |
| Grant Support | |
ID/Acronym/Agency:
|
P-05-111-N//PHS HHS |
| Chemical | |
Reg. No./Substance:
|
0/Blood Proteins; 0/Neoplasm Proteins; 0/Serum Globulins; 0/alpha-Fetoproteins; 0/alpha-Macroglobulins; 8006-64-2/Turpentine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Sulfomucins and sialomucins in the mucus cells of the alimentary canal in an Indian freshwater major...
Next Document: The influence of mercury and lead compounds on the circadian rhythm of cytoplasmic RNA in hypothalam...