Document Detail

Synthesis rates of albumin and fibrinogen in patients with cardiac and pulmonary cachexia.
MedLine Citation:
PMID:  855627     Owner:  NLM     Status:  MEDLINE    
In five patients with chronic congestive heart failure or pulmonary insufficiency and otherwise unexplained weight loss synthesis rates of albumin and fibrinogen were studied with the 14C carbonate method described by Mc Farlane and Reeve. The following results were obtained. 1. Albumin synthesis rate was normal in 4 out of five patients. In one patient with proteinuria and low serum albumin it was markedly increased. 2. Fibrinogen synthesis rate was normal in three out of five patients. In two patients who had active inflammation just before or during the study it was increased. The results suggest, that in chronic congestive heart failure or pulmonary insufficiency the liver is able to maintain normal or even increased protein synthesis rates.
G Mayer; H Schomerus
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta hepato-gastroenterologica     Volume:  24     ISSN:  0300-970X     ISO Abbreviation:  Acta Hepatogastroenterol (Stuttg)     Publication Date:  1977 Apr 
Date Detail:
Created Date:  1977-06-22     Completed Date:  1977-06-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0340734     Medline TA:  Acta Hepatogastroenterol (Stuttg)     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  82-5     Citation Subset:  IM    
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MeSH Terms
Albumins / biosynthesis*
Cachexia / metabolism*
Fibrinogen / biosynthesis*
Heart Failure / metabolism*
Liver / metabolism
Lung Diseases / metabolism*
Middle Aged
Reg. No./Substance:
0/Albumins; 9001-32-5/Fibrinogen

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