Document Detail


Synthesis of the putative metabolites of plant sterols: (24R)- and (24S)-24-methyl-5 beta-cholestane-3 alpha,7 alpha,12 alpha,25-tetrols and 24-ethyl-5 beta-cholestane-3 alpha,7 alpha,12 alpha,24 xi-tetrol.
MedLine Citation:
PMID:  6548507     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This report describes the synthesis of (24R)- and (24S)-24-methyl-5 beta-cholestane-3 alpha,7 alpha,12 alpha,25-tetrols and 24-ethyl-5 beta-cholestane-3 alpha,7 alpha,12 alpha,24 xi-tetrol starting from cholic acid. The bile alcohols epimeric at C-24 were resolved by analytical and preparative thin-layer chromatography and characterized by gas-liquid chromatography and mass spectrometry. These epimeric bile alcohols may be useful for studying the transformation of beta-sitosterol to cholic acid.
Authors:
B Dayal; G Salen; G S Tint; A K Batta; S Shefer
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of lipid research     Volume:  25     ISSN:  0022-2275     ISO Abbreviation:  J. Lipid Res.     Publication Date:  1984 Aug 
Date Detail:
Created Date:  1984-12-05     Completed Date:  1984-12-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376606     Medline TA:  J Lipid Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  865-70     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cholestanols / chemical synthesis*
Humans
Phytosterols / chemical synthesis*,  metabolism
Sitosterols / metabolism
Grant Support
ID/Acronym/Agency:
AM-18707/AM/NIADDK NIH HHS; AM-26756/AM/NIADDK NIH HHS; HL-17818/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Cholestanols; 0/Phytosterols; 0/Sitosterols; 5779-62-4/sitosterol; 93522-96-4/24-methylcholestane-3,7,12,25-tetrol; 93522-97-5/24-ethylcholestane-3,7,12,24-tetrol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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