| Synthesis of protected gamma-carboxyglutamates and gamma-acylglutamates by rearrangement of N,N-diacylglutamates. | |
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MedLine Citation:
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PMID: 16010368 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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A new method for gamma-acylation of protected glutamic acids, involving intramolecular rearrangement of an acyl urethane, has been devised to prepare the protected gamma-carboxyglutamates 7, 9 and 11 and the protected 4-acylglutamates 15 and 22 from N,N-bisurethanes or N-acyl-N-urethanes of general structure 1. When the formyl-urethane 17 was used in the reaction, then the intermediate 18 in the intramolecular rearrangement was obtained. |
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Authors:
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Anthony G Avent; Heather M E Duggan; Douglas W Young |
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Publication Detail:
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Type: Journal Article Date: 2005-05-19 |
Journal Detail:
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Title: Organic & biomolecular chemistry Volume: 3 ISSN: 1477-0520 ISO Abbreviation: Org. Biomol. Chem. Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2005-07-12 Completed Date: 2005-11-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101154995 Medline TA: Org Biomol Chem Country: England |
Other Details:
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Languages: eng Pagination: 2327-32 Citation Subset: - |
Affiliation:
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Department of Chemistry, University of Sussex, Falmer, Brighton, UKBN1 9QJ. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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