| Synthesis of prostaglandins and eicosanoids by the mast cell secretory granule. | |
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MedLine Citation:
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PMID: 3190706 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The identification of a non-bilayer phospholipid storage in the secretory granule and the linking of the eicosanoid production with the release of histamine have prompted us to examine whether the secretory granule may also serve as both the source as well as the site of prostaglandin synthesis during exocytosis. By exposing the contents of purified granules to exogenous arachidonic acid at neutral pH, we observed the rapid formation of many eicosanoids. The presence of prostaglandins E2, D2 and F2a were identified. The kinetics of E2 formation was also followed. The localization of the arachidonic acid cascade to the secretory granule explains why the production of eicosanoids is so intimately tied to the process of granule exocytosis. |
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Authors:
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S P Chock; E A Schmauder-Chock |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 156 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 1988 Nov |
Date Detail:
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Created Date: 1988-12-14 Completed Date: 1988-12-14 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1308-15 Citation Subset: IM |
Affiliation:
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Department of Experimental Hematology, Armed Forces Radiobiology Research Institute, Bethesda, MD 20814-5145. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Autoradiography Cytoplasmic Granules / metabolism* Dinoprost / biosynthesis Dinoprostone / biosynthesis Eicosanoic Acids / biosynthesis* Mast Cells / metabolism*, ultrastructure Microscopy, Electron Phospholipids / metabolism Prostaglandin D2 / biosynthesis Prostaglandins / biosynthesis* Rats Rats, Inbred Strains Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Eicosanoic Acids; 0/Phospholipids; 0/Prostaglandins; 363-24-6/Dinoprostone; 41598-07-6/Prostaglandin D2; 551-11-1/Dinoprost |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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