Document Detail


Synthesis of prostaglandins and eicosanoids by the mast cell secretory granule.
MedLine Citation:
PMID:  3190706     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The identification of a non-bilayer phospholipid storage in the secretory granule and the linking of the eicosanoid production with the release of histamine have prompted us to examine whether the secretory granule may also serve as both the source as well as the site of prostaglandin synthesis during exocytosis. By exposing the contents of purified granules to exogenous arachidonic acid at neutral pH, we observed the rapid formation of many eicosanoids. The presence of prostaglandins E2, D2 and F2a were identified. The kinetics of E2 formation was also followed. The localization of the arachidonic acid cascade to the secretory granule explains why the production of eicosanoids is so intimately tied to the process of granule exocytosis.
Authors:
S P Chock; E A Schmauder-Chock
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  156     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1988 Nov 
Date Detail:
Created Date:  1988-12-14     Completed Date:  1988-12-14     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1308-15     Citation Subset:  IM    
Affiliation:
Department of Experimental Hematology, Armed Forces Radiobiology Research Institute, Bethesda, MD 20814-5145.
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MeSH Terms
Descriptor/Qualifier:
Animals
Autoradiography
Cytoplasmic Granules / metabolism*
Dinoprost / biosynthesis
Dinoprostone / biosynthesis
Eicosanoic Acids / biosynthesis*
Mast Cells / metabolism*,  ultrastructure
Microscopy, Electron
Phospholipids / metabolism
Prostaglandin D2 / biosynthesis
Prostaglandins / biosynthesis*
Rats
Rats, Inbred Strains
Time Factors
Chemical
Reg. No./Substance:
0/Eicosanoic Acids; 0/Phospholipids; 0/Prostaglandins; 363-24-6/Dinoprostone; 41598-07-6/Prostaglandin D2; 551-11-1/Dinoprost

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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