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Synthesis and properties of peptide dendrimers containing fluorescent and branched amino acids.
MedLine Citation:
PMID:  23335168     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
In this report, we describe dendritic peptides possessing central fluorescent amino acids with adjacent branched amino acids. These fluorescent-peptide dendrimers were prepared using (9-fluorenyl)methoxycarbonyl (Fmoc)-based solid-phase peptide synthesis and Fmoc-derivative fluorescent and branched amino acids. The branched amino acids featured multiple carboxylic acids in their side chains, making the fluorescent-peptide dendrimers highly water-soluble compared with the analogous peptides containing the fluorescent amino acids only. The branched amino acid units also improved the fluorescence intensity of the dendrimers. Based on high-pressure liquid chromatography and fluorescence spectroscopy results, we determined that the fluorescent groups were located in the core and that the carboxylic acids were located on the surface of the dendrimers. Fluorescence resonance energy transfer was achieved among the three proximal fluorescent groups in one of the fabricated fluorescent-peptide dendrimers. © 2012 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 100: 64-70, 2013.
Authors:
Mizuki Kitamatsu; Mayumi Kitabatake; Yoshiteru Noutoshi; Takashi Ohtsuki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biopolymers     Volume:  100     ISSN:  0006-3525     ISO Abbreviation:  Biopolymers     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-01-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372525     Medline TA:  Biopolymers     Country:  United States    
Other Details:
Languages:  eng     Pagination:  64-70     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
Affiliation:
Department of Applied Chemistry, Kinki University, 3-4-1 Kowakae, Higashi-Osaka, Osaka 577-8502, Japan. kitamatu@ apch.kindai.ac.jp.
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