| Synthesis and properties of novel psoralen derivatives. | |
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MedLine Citation:
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PMID: 3196695 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have synthesized a set of new trimethylpsoralen derivatives that are characterized by a chain extending from the 4'-position of the furan ring and linked to this ring by an aminomethylene group. The nature of the side chain can be varied widely. In these derivatives, the chains contain either amino or ethylene oxide units for enhanced water solubility and allow the introduction of a thiol or amine group to nucleic acids. These compounds represent the first set of thiolated psoralen derivatives, and their usefulness is demonstrated in several nucleic acid cross-linking experiments. The reagents can be used to create both intraduplex reversible cross-links between the two single-strand partners in a DNA double helix and interduplex reversible cross-links between two DNA double helices. |
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Authors:
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M Goldenberg; J Welsh; R Haas; D C Rideout; C R Cantor |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biochemistry Volume: 27 ISSN: 0006-2960 ISO Abbreviation: Biochemistry Publication Date: 1988 Sep |
Date Detail:
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Created Date: 1989-01-17 Completed Date: 1989-01-17 Revised Date: 2000-12-18 |
Medline Journal Info:
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Nlm Unique ID: 0370623 Medline TA: Biochemistry Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 6971-6 Citation Subset: IM |
Affiliation:
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Department of Chemistry, Columbia University, New York, New York 10027. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cross-Linking Reagents DNA / drug effects* Photochemistry Psoralens / pharmacology* Solubility Sulfhydryl Compounds Trioxsalen / analogs & derivatives, chemical synthesis, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Cross-Linking Reagents; 0/Psoralens; 0/Sulfhydryl Compounds; 3902-71-4/Trioxsalen; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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