Document Detail

Synthesis and properties of amphiphilic networks 2: a differential scanning calorimetric study of poly(dodecyl methacrylate-stat-2,3 propandiol-1-methacrylate-stat-ethandiol dimethacrylate) networks and adhesion and spreading of dermal fibroblasts on these materials.
MedLine Citation:
PMID:  12099296     Owner:  NLM     Status:  MEDLINE    
A series of amphiphilic networks was prepared by radical copolymerisation of dodecyl methacrylate, 2,3-propandiol-1-methacrylate and ethandiol dimethacrylate. DSC studies on these materials, swollen in water. revealed that only materials containing more than 27 wt% of water displayed melting endotherms due to the melting of ice-like structures of water (freezing water). In materials that did produce a melting endotherm the peak was generally bimodal. Changing thermal history and heating rate did not effect the shape of the two peaks, nor the relative contribution of each peak to the total endothermic response. These observations and the narrow peak width of the low temperature endotherm suggested that the bimodality was an artefact of the DSC experiment and may be due to the promotion of the glass transition once a fraction of the water has frozen. The morphology of transformed human dermal fibroblasts grown on these materials was then examined by scanning electron microscopy. Compositions that contained only non-freezing water were found to allow cell adhesion and spreading. Cells with well-spread morphologies were obtained on materials containing small fractions of freezing water and dodecyl methacrylate. These fibroblasts displayed surface features such as microvilli and filapodia. However, all compositions of poly(2,3-propandiol-1-methacrylate-co-ethandiol dimethacrylate) (i.e. hydrogels that do not contain dodecyl methacrylate repeat units) were poor substrates for cell growth and examination of these materials showed that very few cells had adhered and those that did were highly rounded.
R Haigh; N Fullwood; S Rimmer
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Biomaterials     Volume:  23     ISSN:  0142-9612     ISO Abbreviation:  Biomaterials     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-07-08     Completed Date:  2003-01-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8100316     Medline TA:  Biomaterials     Country:  England    
Other Details:
Languages:  eng     Pagination:  3509-16     Citation Subset:  IM    
Department of Biological Sciences, University of Lancaster, UK.
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MeSH Terms
Biocompatible Materials / chemical synthesis*,  chemistry
Calorimetry, Differential Scanning / methods
Hydrogels / chemical synthesis,  chemistry
Microscopy, Electron, Scanning
Polymethyl Methacrylate / chemical synthesis*,  chemistry*
Structure-Activity Relationship
Reg. No./Substance:
0/Biocompatible Materials; 0/Hydrogels; 9011-14-7/Polymethyl Methacrylate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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