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Synthesis of ppTppp via phosphotriester intermediates.
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MedLine Citation:
PMID:  6647028     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The bifunctional and crystalline phosphorylating agent morpholino-0,0-bis[1-benzotriazolyl]phosphate has been used for the preparation of a 3',5'-bis-phosphotriester intermediate of thymidine. The latter has been converted into ppTppp by the following consecutive steps; removal of the benzotriazolyl group followed by the addition of phosphoric acid and removal of the 2-(4-nitrophenyl)-ethyl group followed by the addition of pyrophosphoric acid.
Authors:
C Schattenkerk; G M Visser; G A van der Marel; J H van Boom
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nucleic acids research     Volume:  11     ISSN:  0305-1048     ISO Abbreviation:  Nucleic Acids Res.     Publication Date:  1983 Nov 
Date Detail:
Created Date:  1984-01-07     Completed Date:  1984-01-07     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0411011     Medline TA:  Nucleic Acids Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  7545-54     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Indicators and Reagents
Magnetic Resonance Spectroscopy
Stereoisomerism
Thymidine
Thymine Nucleotides / chemical synthesis*
Chemical
Reg. No./Substance:
0/Indicators and Reagents; 0/Thymine Nucleotides; 50-89-5/Thymidine; 73909-63-4/thymidine-5'-tri-3'-diphosphate
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): Nucleic Acids Res
ISSN: 0305-1048
ISSN: 1362-4962
Article Information
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Print publication date: Day: 11 Month: 11 Year: 1983
Volume: 11 Issue: 21
First Page: 7545 Last Page: 7554
ID: 326501
PubMed Id: 6647028

Synthesis of ppTppp via phosphotriester intermediates.
C Schattenkerk
G M Visser
G A van der Marel
J H van Boom



Article Categories:
  • Research Article


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