Document Detail


Synthesis of polymeric thiazolidinediones and L-ascorbic acid towards the development of insulin-sensitizer.
MedLine Citation:
PMID:  15918508     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Polymers, containing 5-(4-O-methylacryloylbenzyl)thiazolidine-2,4-dione [MABTZD]; poly (MABTZD), poly(MABTZD-co-AA) and poly(MABTZD-co-AMAA), were prepared, and identified by FT-IR, 1H- and 13C-NMR spectra. The MABTZD unit contents in poly(MABTZD-co-AA) and poly(MABZD-co-AMAA) were 11.3 and 27.7 mol %, respectively. The number average molecular weights of the polymers, as determined by GPC, ranged from 16,800 to 22,300, and with polydispersity indices of 1.2-1.4.
Authors:
Sun Mi Lee; Raok Jeon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of pharmacal research     Volume:  28     ISSN:  0253-6269     ISO Abbreviation:  Arch. Pharm. Res.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-05-27     Completed Date:  2005-07-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8000036     Medline TA:  Arch Pharm Res     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  377-81     Citation Subset:  IM    
Affiliation:
College of Pharmacy, Sookmyung Women's University, Seoul 140-742, Korea.
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MeSH Terms
Descriptor/Qualifier:
Animals
Ascorbic Acid / chemistry*
Cell Line
Cercopithecus aethiops
Drug Stability
Hypoglycemic Agents / chemical synthesis*,  chemistry,  pharmacology
Molecular Structure
Molecular Weight
PPAR gamma / metabolism*
Polymers / chemical synthesis*,  chemistry,  pharmacology
Thiazolidinediones / chemical synthesis*,  chemistry,  pharmacology
Chemical
Reg. No./Substance:
0/Hypoglycemic Agents; 0/PPAR gamma; 0/Polymers; 0/Thiazolidinediones; 50-81-7/Ascorbic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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