| Synthesis of phosphonic analogues of carnitine and gamma-amino-beta-hydroxybutyric acid. | |
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MedLine Citation:
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PMID: 15530988 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The involvement of carnitine and gamma-amino-beta-hydroxybutyric acid in the biology of mammalian cells, the physiology of the human body, and some important aspects of medicinal treatment has induced many research groups to develop their pharmacologically potent analogues. Among them are the very important phosphonic analogues: phosphocarnitine and gamma-amino-beta-hydroxypropylphosphonic acid. This mini-review describes the various methodologies used for the synthesis of these compounds. |
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Authors:
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Elzbieta J Tadeusiak |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Bioorganic chemistry Volume: 32 ISSN: 0045-2068 ISO Abbreviation: Bioorg. Chem. Publication Date: 2004 Dec |
Date Detail:
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Created Date: 2004-11-08 Completed Date: 2005-09-22 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 1303703 Medline TA: Bioorg Chem Country: United States |
Other Details:
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Languages: eng Pagination: 473-82 Citation Subset: IM |
Affiliation:
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Department of Structural Studies, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, 90-363 Łódź, Poland. elatad@bilbo.cbmm.lodz.pl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Carnitine
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analogs & derivatives*,
chemical synthesis Molecular Conformation Phosphonic Acids / chemical synthesis*, chemistry* gamma-Aminobutyric Acid / analogs & derivatives*, chemical synthesis, chemistry |
| Chemical | |
Reg. No./Substance:
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0/Phosphonic Acids; 0/phosphocarnitine; 352-21-6/4-amino-3-hydroxybutyric acid; 541-15-1/Carnitine; 56-12-2/gamma-Aminobutyric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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