Document Detail


Synthesis of phosphonic analogues of carnitine and gamma-amino-beta-hydroxybutyric acid.
MedLine Citation:
PMID:  15530988     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The involvement of carnitine and gamma-amino-beta-hydroxybutyric acid in the biology of mammalian cells, the physiology of the human body, and some important aspects of medicinal treatment has induced many research groups to develop their pharmacologically potent analogues. Among them are the very important phosphonic analogues: phosphocarnitine and gamma-amino-beta-hydroxypropylphosphonic acid. This mini-review describes the various methodologies used for the synthesis of these compounds.
Authors:
Elzbieta J Tadeusiak
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Bioorganic chemistry     Volume:  32     ISSN:  0045-2068     ISO Abbreviation:  Bioorg. Chem.     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-11-08     Completed Date:  2005-09-22     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  1303703     Medline TA:  Bioorg Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  473-82     Citation Subset:  IM    
Affiliation:
Department of Structural Studies, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, 90-363 Łódź, Poland. elatad@bilbo.cbmm.lodz.pl
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MeSH Terms
Descriptor/Qualifier:
Carnitine / analogs & derivatives*,  chemical synthesis
Molecular Conformation
Phosphonic Acids / chemical synthesis*,  chemistry*
gamma-Aminobutyric Acid / analogs & derivatives*,  chemical synthesis,  chemistry
Chemical
Reg. No./Substance:
0/Phosphonic Acids; 0/phosphocarnitine; 352-21-6/4-amino-3-hydroxybutyric acid; 541-15-1/Carnitine; 56-12-2/gamma-Aminobutyric Acid

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