Document Detail


Synthesis and pharmacological studies of some 2-t-amino and 2,3-di-t-amino substituted 1,4-naphthoquinones and related compounds.
MedLine Citation:
PMID:  12426819     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Series of 2-t-amino and 2,3-di-t-amino substituted-1,4-naphthoquinones have been synthesised from corresponding 1,4-naphthoquinones by reaction with secondary amines. The compounds have been evaluated for their broad spectrum antimicrobial, antiviral and anticancer activity. In the preliminary screening results 8a and 9a have shown profile of an antimicrobial agent.
Authors:
V K Tandon; R V Singh; S Rai; R B Chhor; Z K Khan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bollettino chimico farmaceutico     Volume:  141     ISSN:  0006-6648     ISO Abbreviation:  Boll Chim Farm     Publication Date:    2002 Jul-Aug
Date Detail:
Created Date:  2002-11-12     Completed Date:  2002-12-10     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0372534     Medline TA:  Boll Chim Farm     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  304-10     Citation Subset:  IM    
Affiliation:
Medicinal Chemistry Research Laboratory, Department of Chemistry, Lucknow University, Lucknow, India.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Bacterial Agents
Anti-Infective Agents / chemical synthesis*,  pharmacology*
Antifungal Agents / chemical synthesis,  pharmacology
Antineoplastic Agents / chemical synthesis,  pharmacology
Antiviral Agents / chemical synthesis,  pharmacology
Bacteria / drug effects
Carcinoma 256, Walker / drug therapy
Drug Screening Assays, Antitumor
Fungi / drug effects
Indicators and Reagents
Microbial Sensitivity Tests
Naphthoquinones / chemical synthesis*,  pharmacology*
Plaque Assay
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Anti-Infective Agents; 0/Antifungal Agents; 0/Antineoplastic Agents; 0/Antiviral Agents; 0/Indicators and Reagents; 0/Naphthoquinones

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