Document Detail


Synthesis and pharmacological evaluation of some 3-(4-methylphenyl)-2-substituted amino-3H-quinazolin-4-ones as analgesic and anti-inflammatory agents.
MedLine Citation:
PMID:  17206609     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A variety of 3-(4-methyl phenyl)-2-substituted amino-3H-quinazolin-4-ones were synthesized by reacting the amino group of 2-hydrazino-3-(4-methyl phenyl)-3H-quinazolin-4-one with a variety of aldehydes and ketones. The starting material 2-hydrazino-3-(4-methyl phenyl)-3H-quinazolin-4-one was synthesized from 4-methyl aniline. The title compounds were investigated for analgesic, anti-inflammatory, and ulcerogenic index activities. While the test compounds exhibited significant activity, compounds Al, A2, and A3 showed more potent analgesic activity and the compound A3 showed more potent anti-inflammatory activity when compared to the reference standard diclofenac sodium. Interestingly, the test compounds showed only mild ulcerogenic potential when compared to aspirin.
Authors:
Veerachamy Alagarsamy; Durairaj Shankar; Muthuvel Murugan; Anees Ahmed Siddiqui; Ramadoss Rajesh
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Archiv der Pharmazie     Volume:  340     ISSN:  0365-6233     ISO Abbreviation:  Arch. Pharm. (Weinheim)     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-04-11     Completed Date:  2007-05-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0330167     Medline TA:  Arch Pharm (Weinheim)     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  41-6     Citation Subset:  IM    
Affiliation:
Medicinal Chemistry Research Laboratory, Arulmigu Kalasalingam College of Pharmacy, Anand Nagar, Krishnankovil, India. samy_veera@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Analgesics / chemical synthesis*,  pharmacology,  toxicity
Animals
Anti-Inflammatory Agents / chemical synthesis*,  pharmacology,  toxicity
Aspirin / toxicity
Carrageenan
Diclofenac / pharmacology
Disease Models, Animal
Edema / chemically induced,  prevention & control
Male
Mice
Molecular Structure
Pain Measurement
Pain Threshold / drug effects
Quinazolinones / chemical synthesis*,  pharmacology,  toxicity
Rats
Rats, Wistar
Stomach Ulcer / chemically induced
Chemical
Reg. No./Substance:
0/Analgesics; 0/Anti-Inflammatory Agents; 0/Quinazolinones; 15307-86-5/Diclofenac; 50-78-2/Aspirin; 9000-07-1/Carrageenan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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