Document Detail


Synthesis and pharmacological evaluation of (2-oxaadamant-1-yl)amines.
MedLine Citation:
PMID:  19251424     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The synthesis of several (2-oxaadamant-1-yl)amines is reported. They were evaluated as NMDA receptor antagonists and several of them were more active than amantadine, but none was more potent than memantine. None of the tested compounds displayed antiviral activity. Two of the derivatives showed a significant level of trypanocidal activity.
Authors:
María D Duque; Pelayo Camps; Lenuta Profire; Silvia Montaner; Santiago Vázquez; Francesc X Sureda; Jordi Mallol; Marta López-Querol; Lieve Naesens; Erik De Clercq; S Radhika Prathalingam; John M Kelly
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-02-13
Journal Detail:
Title:  Bioorganic & medicinal chemistry     Volume:  17     ISSN:  1464-3391     ISO Abbreviation:  Bioorg. Med. Chem.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-04-13     Completed Date:  2009-12-17     Revised Date:  2013-04-12    
Medline Journal Info:
Nlm Unique ID:  9413298     Medline TA:  Bioorg Med Chem     Country:  England    
Other Details:
Languages:  eng     Pagination:  3198-206     Citation Subset:  IM    
Affiliation:
Laboratori de Química Farmacèutica (Unitat Associada al CSIC), Facultat de Farmàcia, and Institute of Biomedicine (IBUB), Universitat de Barcelona, Av. Diagonal, 643, Barcelona E-08028, Spain.
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MeSH Terms
Descriptor/Qualifier:
Adamantane / analogs & derivatives*,  chemical synthesis,  pharmacology*
Amines / chemical synthesis*,  pharmacology*
Animals
Antiviral Agents / chemical synthesis,  pharmacology
Cell Culture Techniques
Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors,  metabolism
Trypanocidal Agents / chemical synthesis,  pharmacology
Grant Support
ID/Acronym/Agency:
084175//Wellcome Trust; //Wellcome Trust
Chemical
Reg. No./Substance:
0/Amines; 0/Antiviral Agents; 0/Receptors, N-Methyl-D-Aspartate; 0/Trypanocidal Agents; 281-23-2/Adamantane
Comments/Corrections

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