| Synthesis and pharmacological evaluation of 1,2,4-triazine and its congeners. | |
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MedLine Citation:
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PMID: 7734126 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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3-[Mercapto]-n-propanoxy/methyl-ethanoxy branched chain in 5,6-Diphenyl- 1,2,4-triazine were condensed with O-phenylene diamine or O- aminophenol or o-aminothiophenol. The carboxylic groups of the synthesized compounds were cyclised to yield imidazoles, oxazoles and thiazoles. They were screened for their anti-inflammatory response in albino rats against carrageenin induced paw oedema. The active compounds were also evaluated for their ED50 value in albino rats and analgesic activity in albino mice. The compounds exhibited significant anti-inflammatory activity also showed marked protection against aconitine induced writhing response. The potent compounds showed high LD50 values. |
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Authors:
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M Bhalla; V K Srivastava; T N Bhalla; K Shanker |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Bollettino chimico farmaceutico Volume: 134 ISSN: 0006-6648 ISO Abbreviation: Boll Chim Farm Publication Date: 1995 Jan |
Date Detail:
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Created Date: 1995-06-07 Completed Date: 1995-06-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372534 Medline TA: Boll Chim Farm Country: ITALY |
Other Details:
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Languages: eng Pagination: 9-15 Citation Subset: IM |
Affiliation:
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Department of Pharmacology and Therapeutics K.G.'s Medical College Lucknow, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*, pharmacology, toxicity Isomerism Mice Rats Stomach Ulcer / chemically induced, pathology Triazines / chemical synthesis*, pharmacology, toxicity |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 0/Triazines; 290-38-0/1,2,4-triazine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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