Document Detail


Synthesis and pharmacological evaluation of 1,2,4-triazine and its congeners.
MedLine Citation:
PMID:  7734126     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
3-[Mercapto]-n-propanoxy/methyl-ethanoxy branched chain in 5,6-Diphenyl- 1,2,4-triazine were condensed with O-phenylene diamine or O- aminophenol or o-aminothiophenol. The carboxylic groups of the synthesized compounds were cyclised to yield imidazoles, oxazoles and thiazoles. They were screened for their anti-inflammatory response in albino rats against carrageenin induced paw oedema. The active compounds were also evaluated for their ED50 value in albino rats and analgesic activity in albino mice. The compounds exhibited significant anti-inflammatory activity also showed marked protection against aconitine induced writhing response. The potent compounds showed high LD50 values.
Authors:
M Bhalla; V K Srivastava; T N Bhalla; K Shanker
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bollettino chimico farmaceutico     Volume:  134     ISSN:  0006-6648     ISO Abbreviation:  Boll Chim Farm     Publication Date:  1995 Jan 
Date Detail:
Created Date:  1995-06-07     Completed Date:  1995-06-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372534     Medline TA:  Boll Chim Farm     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  9-15     Citation Subset:  IM    
Affiliation:
Department of Pharmacology and Therapeutics K.G.'s Medical College Lucknow, India.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*,  pharmacology,  toxicity
Isomerism
Mice
Rats
Stomach Ulcer / chemically induced,  pathology
Triazines / chemical synthesis*,  pharmacology,  toxicity
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Triazines; 290-38-0/1,2,4-triazine

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