Document Detail

Synthesis of peptide ribonucleic acid consisting of D- and L-gamma-glutamic acid as a backbone structure.
MedLine Citation:
PMID:  17150461     Owner:  NLM     Status:  MEDLINE    
A novel nucleic acid model using peptide ribonucleic acid (PRNA), which contains 5-amino-5-deoxyribonucleoside as a recognition site for nucleic acids and consists D-glutamic acid (D-PRNA) instead of L-glutamic acid (L-PRNA) as a backbone structure, has been designed and synthesized. Difference between D-PRNA and L-PRNA oligomers was elucidated on the basis of the effects of chirality of gamma-glutamic acid backbone upon structure elucidated by CD spectra.
Takehiko Wada; Yusuke Hashimoto; Hirofumi Sato; Yoshihisa Inoue
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nucleic acids symposium series (2004)     Volume:  -     ISSN:  1746-8272     ISO Abbreviation:  Nucleic Acids Symp Ser (Oxf)     Publication Date:  2004  
Date Detail:
Created Date:  2006-12-07     Completed Date:  2007-07-19     Revised Date:  2007-09-19    
Medline Journal Info:
Nlm Unique ID:  101259965     Medline TA:  Nucleic Acids Symp Ser (Oxf)     Country:  England    
Other Details:
Languages:  eng     Pagination:  27-8     Citation Subset:  IM    
PRESTO, JST, Yamada-oka, Suita 565-0871, Japan.
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MeSH Terms
Circular Dichroism
Glutamic Acid / chemistry*
Hydrogen-Ion Concentration
Nucleic Acid Conformation*
Peptide Nucleic Acids / chemical synthesis*,  chemistry
RNA / chemical synthesis*,  chemistry
Reg. No./Substance:
0/Buffers; 0/Peptide Nucleic Acids; 56-86-0/Glutamic Acid; 63231-63-0/RNA

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