Document Detail


Synthesis of pathogen inactivating nucleic acid intercalators.
MedLine Citation:
PMID:  15501547     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A series of antiviral compounds consisting of an intercalating acridine derived part, a spacer region and a reactive EDTA-derived conjugate was synthesized in an easy sequence starting from 1,omega-alkyldiamines. As shown in model screenings, in the presence of ascorbic acid the Fe-complexes of these compounds reduced the phage-titer of MS2-phages by several logarithmic decades.
Authors:
René Csuk; Alexander Barthel; Thorsten Brezesinski; Christian Raschke
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of medicinal chemistry     Volume:  39     ISSN:  0223-5234     ISO Abbreviation:  Eur J Med Chem     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-10-25     Completed Date:  2005-03-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0420510     Medline TA:  Eur J Med Chem     Country:  France    
Other Details:
Languages:  eng     Pagination:  975-88     Citation Subset:  IM    
Affiliation:
Institut für Organische Chemie, Martin-Luther-Universität Halle-Wittenberg, Kurt-Mothes-Strasse 2, 06120 Halle (Saale), Germany. csuk@chemie.uni-halle.de
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MeSH Terms
Descriptor/Qualifier:
Acridines / chemical synthesis*,  chemistry,  pharmacology
Antiviral Agents / chemical synthesis*,  chemistry,  pharmacology
Ascorbic Acid / metabolism
Edetic Acid / chemistry
Intercalating Agents / chemical synthesis*,  chemistry,  pharmacology
Iron / metabolism
Levivirus / drug effects*
Nucleic Acids / drug effects*
Chemical
Reg. No./Substance:
0/Acridines; 0/Antiviral Agents; 0/Intercalating Agents; 0/Nucleic Acids; 50-81-7/Ascorbic Acid; 60-00-4/Edetic Acid; 7439-89-6/Iron

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