| Synthesis of pathogen inactivating nucleic acid intercalators. | |
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MedLine Citation:
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PMID: 15501547 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A series of antiviral compounds consisting of an intercalating acridine derived part, a spacer region and a reactive EDTA-derived conjugate was synthesized in an easy sequence starting from 1,omega-alkyldiamines. As shown in model screenings, in the presence of ascorbic acid the Fe-complexes of these compounds reduced the phage-titer of MS2-phages by several logarithmic decades. |
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Authors:
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René Csuk; Alexander Barthel; Thorsten Brezesinski; Christian Raschke |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of medicinal chemistry Volume: 39 ISSN: 0223-5234 ISO Abbreviation: Eur J Med Chem Publication Date: 2004 Nov |
Date Detail:
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Created Date: 2004-10-25 Completed Date: 2005-03-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0420510 Medline TA: Eur J Med Chem Country: France |
Other Details:
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Languages: eng Pagination: 975-88 Citation Subset: IM |
Affiliation:
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Institut für Organische Chemie, Martin-Luther-Universität Halle-Wittenberg, Kurt-Mothes-Strasse 2, 06120 Halle (Saale), Germany. csuk@chemie.uni-halle.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acridines
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chemical synthesis*,
chemistry,
pharmacology Antiviral Agents / chemical synthesis*, chemistry, pharmacology Ascorbic Acid / metabolism Edetic Acid / chemistry Intercalating Agents / chemical synthesis*, chemistry, pharmacology Iron / metabolism Levivirus / drug effects* Nucleic Acids / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Acridines; 0/Antiviral Agents; 0/Intercalating Agents; 0/Nucleic Acids; 50-81-7/Ascorbic Acid; 60-00-4/Edetic Acid; 7439-89-6/Iron |
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