| Synthesis of oxy-peptide nucleic acids with mixed sequences. | |
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MedLine Citation:
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PMID: 10780364 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Syntheses of N-Fmoc delta-amino acids with an ether linkage in the main chain and six different nucleobases on the side chain, Fmoc-NH-C*H(CH2-CH2-B)-CH2-O-CH2-COOH (B = N6-benzoyladenine, thymine, uracil, N-benzoylcytosine, guanine, and N2-isobutyrylguanine) are described. The delta-amino acids were prepared through 8-12 step synthesis starting from L-homoserine and could be linked together to form novel peptide nucleic acids (oxy-PNAs = OPNAs) by solid-phase peptide synthesis. |
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Authors:
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M Kuwahara; M Arimitsu; M Sigeyasu; M Sisido |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nucleic acids symposium series Volume: - ISSN: 0261-3166 ISO Abbreviation: Nucleic Acids Symp. Ser. Publication Date: 1999 |
Date Detail:
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Created Date: 2000-06-29 Completed Date: 2000-06-29 Revised Date: 2000-12-18 |
Medline Journal Info:
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Nlm Unique ID: 8007206 Medline TA: Nucleic Acids Symp Ser Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 31-2 Citation Subset: IM |
Affiliation:
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Department of Bioscience and Biotechnology, Faculty of Engineering, Okayama University, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Indicators and Reagents Oligopeptides / chemical synthesis, chemistry Peptide Nucleic Acids / chemical synthesis*, chemistry* Purines Pyrimidines Stereoisomerism |
| Chemical | |
Reg. No./Substance:
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0/Indicators and Reagents; 0/Oligopeptides; 0/Peptide Nucleic Acids; 0/Purines; 0/Pyrimidines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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