Document Detail

Synthesis of oxy-peptide nucleic acids with mixed sequences.
MedLine Citation:
PMID:  10780364     Owner:  NLM     Status:  MEDLINE    
Syntheses of N-Fmoc delta-amino acids with an ether linkage in the main chain and six different nucleobases on the side chain, Fmoc-NH-C*H(CH2-CH2-B)-CH2-O-CH2-COOH (B = N6-benzoyladenine, thymine, uracil, N-benzoylcytosine, guanine, and N2-isobutyrylguanine) are described. The delta-amino acids were prepared through 8-12 step synthesis starting from L-homoserine and could be linked together to form novel peptide nucleic acids (oxy-PNAs = OPNAs) by solid-phase peptide synthesis.
M Kuwahara; M Arimitsu; M Sigeyasu; M Sisido
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nucleic acids symposium series     Volume:  -     ISSN:  0261-3166     ISO Abbreviation:  Nucleic Acids Symp. Ser.     Publication Date:  1999  
Date Detail:
Created Date:  2000-06-29     Completed Date:  2000-06-29     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  8007206     Medline TA:  Nucleic Acids Symp Ser     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  31-2     Citation Subset:  IM    
Department of Bioscience and Biotechnology, Faculty of Engineering, Okayama University, Japan.
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MeSH Terms
Indicators and Reagents
Oligopeptides / chemical synthesis,  chemistry
Peptide Nucleic Acids / chemical synthesis*,  chemistry*
Reg. No./Substance:
0/Indicators and Reagents; 0/Oligopeptides; 0/Peptide Nucleic Acids; 0/Purines; 0/Pyrimidines

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