| Synthesis of optically active dodecaborate-containing l-amino acids for BNCT. | |
MedLine Citation:
|
PMID: 21514832 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
A convenient and simple synthetic method of dodecaboratethio-l-amino acid, a new class of tumor-seeking boron carrier for BNCT, was accomplished from S-cyanoethylthioundecahydro-closo-dodecaborate (S-cyanoethyl-(10)BSH, [(10)B(12)H(11)](2-)SCH(2)CH(2)CN) and bromo-l-α-amino acids by nearly one step S-alkylation. An improved synthesis of S-cyanoethyl-(10)BSH, a key starting compound for S-alkylation, was also performed by Michael addition of (10)BSH with acryronitrile in high yield. Four kinds of new dodecaboratethio-l-amino acids were obtained in optically pure form without the need for any optical resolution. |
Authors:
|
Shintaro Kusaka; Yoshihide Hattori; Kouki Uehara; Tomoyuki Asano; Shinji Tanimori; Mitsunori Kirihata |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-4-8 |
Journal Detail:
|
Title: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine Volume: - ISSN: 1872-9800 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-4-25 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9306253 Medline TA: Appl Radiat Isot Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011. Published by Elsevier Ltd. |
Affiliation:
|
Department of Bioscience and Informatics, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1-1 Gakuen-cho, Nakaku, Sakai, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Improving the separation of Cu(II) from Zn(II) based on an anion exchanger for the preparation a (62...
Next Document: Dissolution and subsequent re-crystallization as zeroing mechanism, thermal properties and component...