| Synthesis of oligodeoxyribonucleotides containing a conformationally-locked anti analogue of O(6)-methyl-2'-deoxyguanosine and their recognition by MGMT and Atl1. | |
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MedLine Citation:
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PMID: 23059787 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We show that DNA containing a conformationally-locked anti analogue of O(6)-alkylguanine is a poor substrate for human O(6)-methylguanine-DNA methyltransferase (MGMT) and the alkyltransferase-like protein, Atl1. This highlights the requirement for the syn conformation and rationalises why certain O(6)-alkylguanines are poor MGMT substrates. |
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Authors:
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Kabir Abdu; Miren K Aiertza; Oliver J Wilkinson; Jane A Grasby; Pattama Senthong; Andrew C Povey; Geoffrey P Margison; David M Williams |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-11 |
Journal Detail:
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Title: Chemical communications (Cambridge, England) Volume: - ISSN: 1364-548X ISO Abbreviation: Chem. Commun. (Camb.) Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9610838 Medline TA: Chem Commun (Camb) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Centre for Chemical Biology, Department of Chemistry, Krebs Institute, University of Sheffield, Sheffield, S3 7HF, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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