Document Detail


Synthesis of oligodeoxyribonucleotides containing a conformationally-locked anti analogue of O(6)-methyl-2'-deoxyguanosine and their recognition by MGMT and Atl1.
MedLine Citation:
PMID:  23059787     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We show that DNA containing a conformationally-locked anti analogue of O(6)-alkylguanine is a poor substrate for human O(6)-methylguanine-DNA methyltransferase (MGMT) and the alkyltransferase-like protein, Atl1. This highlights the requirement for the syn conformation and rationalises why certain O(6)-alkylguanines are poor MGMT substrates.
Authors:
Kabir Abdu; Miren K Aiertza; Oliver J Wilkinson; Jane A Grasby; Pattama Senthong; Andrew C Povey; Geoffrey P Margison; David M Williams
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-11
Journal Detail:
Title:  Chemical communications (Cambridge, England)     Volume:  -     ISSN:  1364-548X     ISO Abbreviation:  Chem. Commun. (Camb.)     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610838     Medline TA:  Chem Commun (Camb)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Centre for Chemical Biology, Department of Chemistry, Krebs Institute, University of Sheffield, Sheffield, S3 7HF, UK.
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