| Synthesis of novel test compounds for antiviral chemotherapy of severe acute respiratory syndrome (SARS). | |
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MedLine Citation:
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PMID: 16101496 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This contribution reviews the synthesis of a range of experimental drugs designed for and aiming at antiviral chemotherapy of severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV)-induced human disease conditions. The selection of 25 test materials includes eleven trioxa-adamantane-triols (TATs) [BN, IBNCA, ABNCA, VANBA, ethylVANBA, euBN, euVANBA, ansaBN, Ehrlich BN, [6]prismaneBN, nitrodiBN], trivially termed bananins, one trioxa-adamantan-ol (TAO) THYMOBA, one bis-bananin pi-bananin (piBN), one triazaadamantane delta-bananin (deltaBN), seven potential nucleic acid-binding drugs (XBQC, INDO, PivINDO, AZTRION, AZADO, AZOCYS, AZOGALL), one potential antiviral interferon-inducer and distant nucleoside analog diazon, one potential HIV protein Vif antagonist AZODIAZON, one folic acid-diazon condensate DIAZONOFOL, and one special nucleoside analog (fructoinosine/fructovir). Four of the eleven bananins (BN, IBNCA, VANBA, euBN) were already demonstrated to constitute effective inhibitors of SARS-CoV NSP10/nsp13 RNA/DNA helicase/NTPase protein ATPase enzymatic function. Bananin (BN) was an effective inhibitor of both SARS-CoV RNA/DNA helicase nucleic acid unwinding function and SARS-CoV (Coronaviridae, Coronavirus) RNA-viral replication in cell culture. In summary, at least one selected compound of the synthesized test materials represents an interesting drug candidate for treatment of SARS-CoV-induced human disease (SARS). Viewed in aspects of organic chemistry [6]prismaneBN and nitrodiBN are the first true hexaprismane derivatives synthesized, and all reported compounds are entirely new. |
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Authors:
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Andreas J Kesel |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current medicinal chemistry Volume: 12 ISSN: 0929-8673 ISO Abbreviation: Curr. Med. Chem. Publication Date: 2005 |
Date Detail:
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Created Date: 2005-08-16 Completed Date: 2005-09-29 Revised Date: 2007-02-12 |
Medline Journal Info:
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Nlm Unique ID: 9440157 Medline TA: Curr Med Chem Country: Netherlands |
Other Details:
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Languages: eng Pagination: 2095-162 Citation Subset: IM |
Affiliation:
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andreas.kesel@t-online.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antiviral Agents
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chemical synthesis*,
chemistry*,
pharmacology Humans Molecular Structure Proteomics SARS Virus / chemistry, drug effects*, genetics Severe Acute Respiratory Syndrome / drug therapy*, virology Virus Replication / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Antiviral Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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