| Synthesis of a novel phosphate analog of 20-hydroxylecdysone with potent hypoglycemic activity. | |
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MedLine Citation:
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PMID: 21462032 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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A novel, water-soluble 20-hydroxylecdysono-20,22-phosphoric acid 2 and its sodium salt 3 were designed and synthesized from 20-hydroxylecdysone 1 in six steps and with 67% overall yield. The synthesized phosphoric acid 2 exhibited hypoglycemic activity >40-fold more potent than that of 20-hydroxylecdysone 1 at concentrations between 2 × 10(- 7) and 2 × 10(- 8) mol/l in a glucose consumption test in HepG2 cells. At a concentration of 2 × 10(- 9) mol/l, phosphoric acid 2 was still active, causing a maximum increase in glucose consumption of more than 500%, while 20-hydroxylecdysone 1 was inactive. |
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Authors:
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Dan Zhang; Min Zhang; Bao Ding; Xiao-Lin Wang; Zong-Yin Qiu; Yong Qin |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of Asian natural products research Volume: 13 ISSN: 1477-2213 ISO Abbreviation: J Asian Nat Prod Res Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-04-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888334 Medline TA: J Asian Nat Prod Res Country: England |
Other Details:
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Languages: eng Pagination: 297-303 Citation Subset: IM |
Affiliation:
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Department of Medicinal Natural Products and Key Laboratory of Drug Targeting & Drug Delivery Systems of the Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, China. |
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Descriptor/Qualifier:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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