| Synthesis of novel folic acid-functionalized biocompatible block copolymers by atom transfer radical polymerization for gene delivery and encapsulation of hydrophobic drugs. | |
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MedLine Citation:
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PMID: 15762681 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two synthetic routes to folic acid (FA)-functionalized diblock copolymers based on 2-(methacryloyloxy)ethyl phosphorylcholine [MPC] and either 2-(dimethylamino)ethyl methacrylate [DMA] or 2-(diisopropylamino)ethyl methacrylate [DPA] were explored. The most successful route involved atom transfer radical polymerization (ATRP) of MPC followed by the tertiary amine methacrylate using a 9-fluorenylmethyl chloroformate (Fmoc)-protected ATRP initiator. Deprotection of the Fmoc groups produced terminal primary amine groups, which were conjugated with FA to produce two series of novel FA-functionalized biocompatible block copolymers. Nonfunctionalized MPC-DMA diblock copolymers have been previously shown to be effective synthetic vectors for DNA condensation; thus, these FA-functionalized MPC-DMA diblock copolymers appear to be well suited to gene therapy applications based on cell targeting strategies. In contrast, the FA-MPC-DPA copolymers are currently being evaluated as pH-responsive micellar vehicles for the delivery of highly hydrophobic anticancer drugs. |
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Authors:
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M Licciardi; Y Tang; N C Billingham; S P Armes; A L Lewis |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biomacromolecules Volume: 6 ISSN: 1525-7797 ISO Abbreviation: Biomacromolecules Publication Date: 2005 Mar-Apr |
Date Detail:
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Created Date: 2005-03-14 Completed Date: 2005-08-18 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100892849 Medline TA: Biomacromolecules Country: United States |
Other Details:
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Languages: eng Pagination: 1085-96 Citation Subset: IM |
Affiliation:
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Department of Chemistry, University of Sussex, Falmer, Brighton, BN1 9QJ East Sussex, United Kingdom. m.licciardi@unipa.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biocompatible Materials
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chemical synthesis* Drug Carriers / chemical synthesis* Drug Compounding Folic Acid* Gene Therapy Hydrogen-Ion Concentration Hydrophobicity Molecular Structure Polymers / chemical synthesis*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials; 0/Drug Carriers; 0/Polymers; 59-30-3/Folic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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