Document Detail


Synthesis of a novel class of fatty acids-derived isoquinolines.
MedLine Citation:
PMID:  15921974     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two series of novel tetrahydroisoquinoline derivatives bearing at C-1 position a carbon chain derived from fatty acids were prepared employing two complementary synthetic methodologies. The Pictet-Spengler condensation was performed on myristyl, palmityl, stearyl and oleyl aldehydes, whereas the Bischler-Napieralski cyclization used pelargonic, stearic, linolenic and arachidonic acids. The ability to apply both methods allows further labeling of the final 1-substituted-1,2,3,4-tetrahydroisoquinolines for biological studies.
Authors:
Iwona Matuszewska; Andrzej Leniewski; Piotr Roszkowski; Zbigniew Czarnocki
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Publication Detail:
Type:  Journal Article     Date:  2005-03-05
Journal Detail:
Title:  Chemistry and physics of lipids     Volume:  135     ISSN:  0009-3084     ISO Abbreviation:  Chem. Phys. Lipids     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-05-30     Completed Date:  2005-10-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0067206     Medline TA:  Chem Phys Lipids     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  131-45     Citation Subset:  IM    
Affiliation:
Faculty of Chemistry, Warsaw University, Pasteur St. 1, 02-093 Warsaw, Poland.
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MeSH Terms
Descriptor/Qualifier:
Blood-Brain Barrier / metabolism
Fatty Acids / chemistry
Magnetic Resonance Spectroscopy
Tetrahydroisoquinolines / chemical synthesis*,  chemistry,  pharmacokinetics
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Tetrahydroisoquinolines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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