| Synthesis of a novel class of fatty acids-derived isoquinolines. | |
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MedLine Citation:
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PMID: 15921974 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two series of novel tetrahydroisoquinoline derivatives bearing at C-1 position a carbon chain derived from fatty acids were prepared employing two complementary synthetic methodologies. The Pictet-Spengler condensation was performed on myristyl, palmityl, stearyl and oleyl aldehydes, whereas the Bischler-Napieralski cyclization used pelargonic, stearic, linolenic and arachidonic acids. The ability to apply both methods allows further labeling of the final 1-substituted-1,2,3,4-tetrahydroisoquinolines for biological studies. |
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Authors:
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Iwona Matuszewska; Andrzej Leniewski; Piotr Roszkowski; Zbigniew Czarnocki |
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Publication Detail:
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Type: Journal Article Date: 2005-03-05 |
Journal Detail:
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Title: Chemistry and physics of lipids Volume: 135 ISSN: 0009-3084 ISO Abbreviation: Chem. Phys. Lipids Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2005-05-30 Completed Date: 2005-10-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0067206 Medline TA: Chem Phys Lipids Country: Ireland |
Other Details:
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Languages: eng Pagination: 131-45 Citation Subset: IM |
Affiliation:
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Faculty of Chemistry, Warsaw University, Pasteur St. 1, 02-093 Warsaw, Poland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood-Brain Barrier
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metabolism Fatty Acids / chemistry Magnetic Resonance Spectroscopy Tetrahydroisoquinolines / chemical synthesis*, chemistry, pharmacokinetics |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Tetrahydroisoquinolines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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