Document Detail


Synthesis of novel 6'-spirocyclopropyl-5'-norcarbocyclic adenosine phosphonic Acid analogues as potent anti-hiv agents.
MedLine Citation:
PMID:  21967289     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Novel 5'-norcarbocyclic adenosine phosphonic acid analogues with 6'-electropositive moiety such as spirocyclopropane were designed and synthesized from the commercially available diethylmalonate 5. Regioselective Mitsunobu reaction proceeded in the presence of an allylic functional group at a low reaction temperature in polar cosolvent [dimethylformamide (DMF)/1,4-dioxane] to give purine analogue 15. To improve cellular permeability and enhance the anti-human immunodeficiency virus (HIV) activity of this phosphonic acid, a SATE phosphonodiester nucleoside prodrug 23 was prepared. The synthesized adenosine phosphonic acids analogues 18-21 and 23 were subjected to antiviral screening against HIV-1.
Authors:
Lian Jin Liu; Eunae Kim; Joon Hee Hong
Related Documents :
17834449 - Salicylic acid: a natural inducer of heat production in arum lilies.
21240549 - Invasion of trypanosoma cruzi into host cells is impaired by n-propionylmannosamine and...
23719769 - Universal and facile synthesis of multicolored upconversion hollow nanospheres using no...
8508539 - Battery acid burns of the upper gastro-intestinal tract.
2673619 - Whole-bowel irrigation versus activated charcoal in sorbitol for the ingestion of modif...
10852529 - Sinus tissue pharmacokinetics after oral administration of amoxicillin/clavulanic acid.
11746689 - Reading the three-dimensional structure of lattice model-designed proteins from their a...
8475369 - Analysis of chlorophenoxy acids and other acidic contaminants in food crops.
20621469 - High activity of acid-treated quail eggshell catalysts in the transesterification of pa...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nucleosides, nucleotides & nucleic acids     Volume:  30     ISSN:  1532-2335     ISO Abbreviation:  Nucleosides Nucleotides Nucleic Acids     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100892832     Medline TA:  Nucleosides Nucleotides Nucleic Acids     Country:  United States    
Other Details:
Languages:  eng     Pagination:  784-97     Citation Subset:  IM    
Affiliation:
a BK-21 Project Team, College of Pharmacy, Chosun University , Kwangju , Republic of Korea.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Synthesis and biological activity of the nucleoside analogs based on polyfluoroalkyl-substituted 1,2...
Next Document:  Design and synthesis of carbocyclic versions of furanoid nucleoside phosphonic Acid analogues as pot...