| Synthesis of novel 2'-deoxy type trans-3',4'-bridged nucleic acid. | |
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MedLine Citation:
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PMID: 18058540 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We newly designed and synthesized a 2'-deoxy type trans-3',4'-bridged nucleic acid (trans-3',4'-BNA) analogues bearing a 4,7-dioxabicyclo[4.3.0]nonane structure. The synthesis of the trans-3',4'-BNA was carried out successfully from thymidine over 21 steps. The structure of trans-3',4'-BNA was confirmed by x-ray crystallographic analysis, indicating that the furanose ring has a typical S-type conformation with C(3')-exo puckering. |
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Authors:
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Tomohisa Osaki; Satoshi Obika; Yasuki Harada; Yasunori Mitsuoka; Kensaku Sugaya; Mitsuaki Sekiguchi; Somjing Roongjang; Takeshi Imanishi |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nucleosides, nucleotides & nucleic acids Volume: 26 ISSN: 1525-7770 ISO Abbreviation: Nucleosides Nucleotides Nucleic Acids Publication Date: 2007 |
Date Detail:
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Created Date: 2007-12-06 Completed Date: 2008-03-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100892832 Medline TA: Nucleosides Nucleotides Nucleic Acids Country: United States |
Other Details:
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Languages: eng Pagination: 1079-82 Citation Subset: IM |
Affiliation:
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Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bicyclo Compounds
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chemical synthesis,
chemistry Crystallography, X-Ray Deoxyribonucleosides / chemical synthesis*, chemistry Drug Design Methods Molecular Conformation Molecular Structure Stereoisomerism |
| Chemical | |
Reg. No./Substance:
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0/Bicyclo Compounds; 0/Deoxyribonucleosides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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