Document Detail

Synthesis of new hypoxia markers EF1 and [18F]-EF1.
MedLine Citation:
PMID:  10581679     Owner:  NLM     Status:  MEDLINE    
We report on the preparation of a hypoxia marker 2-(2-nitroimidazol-1[H]-yl)-N-(3-fluoropropyl)acetamide (EF1) and its 18F analog, 2-(2-nitroimidazol-1[H]-yl)-N- (3-[18F]fluoropropyl)acetamide ([18F]-EF1). Two methods for the preparation of 3-fluoropropylamine, the EF1 side chain, are described. [18F]-EF1 was prepared with a radiochemical yield of 2% by nucleophilic substitution of bromine in 2-(2-nitroimidazol-1[H]-yl)-N-(3-bromopropyl)acetamide (EBr1) by carrier-added 18F in DMSO at 120 degrees C. Our results demonstrate the preparation of clinically relevant amounts of [18F]-EF1 for use as a non-invasive hypoxia marker with detection using positron emission tomography (PET).
A V Kachur; W R Dolbier; S M Evans; C Y Shiue; G G Shiue; K A Skov; I R Baird; B R James; A R Li; A Roche; C J Koch
Related Documents :
2531169 - Blepharospasm associated with olivopontocerebellar atrophy.
8496069 - Laboratory and natural heritabilities of male courtship song characters in drosophila m...
19362289 - Anonymous group peer review in surgery morbidity and mortality conference.
18958959 - Religion and spirituality in adjustment following bereavement: an integrative review.
22855699 - Herbal hepatoxicity from chinese skullcap: a case report.
19111109 - Which ventilators and modes can be used to deliver noninvasive ventilation?
25391999 - Developing a framework to review near-miss maternal morbidity in india: a structured re...
18391339 - Open-source shared case library.
10734529 - Protruding urethral leiomyoma obscuring vaginal introitus: case report.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine     Volume:  51     ISSN:  0969-8043     ISO Abbreviation:  Appl Radiat Isot     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-01-11     Completed Date:  2000-01-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9306253     Medline TA:  Appl Radiat Isot     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  643-50     Citation Subset:  IM    
Department of Radiation Oncology, University of Pennsylvania, Philadelphia 19104, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anoxia / diagnosis*,  metabolism
Biological Markers / analysis
Fluorine Radioisotopes / chemistry
Isotope Labeling / methods
Nitroimidazoles / chemical synthesis*
Radiopharmaceuticals / chemical synthesis*
Tomography, Emission-Computed
Reg. No./Substance:
0/2-(2-nitroimidazol-1H-yl)-N-(3-fluoropropyl)acetamide; 0/Biological Markers; 0/Fluorine Radioisotopes; 0/Nitroimidazoles; 0/Radiopharmaceuticals

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Separation of carrier free 151,152Tb produced in 16O irradiated lanthanum oxide matrix.
Next Document:  A new technique for processing airborne gamma ray spectrometry data for mapping low level contaminat...