| Synthesis of a new family of glycolipidic nitrones as potential antioxidant drugs for neurodegenerative disorders. | |
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MedLine Citation:
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PMID: 12617908 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This paper deals with the synthesis of a novel series of amphiphilic glycosylated spin-traps derived from alpha-Phenyl-N-tert-butyl nitrone (PBN) and an initial characterization of their anti-caspase-3 activity. Preliminary investigation of their anti-apoptosis effect showed they dramatically inhibit the activity of caspase-3 in cultured neuronal cells following induction of apoptosis by hydrogen peroxide. |
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Authors:
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Grégory Durand; Ange Polidori; Jean-Pierre Salles; Bernard Pucci |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Bioorganic & medicinal chemistry letters Volume: 13 ISSN: 0960-894X ISO Abbreviation: Bioorg. Med. Chem. Lett. Publication Date: 2003 Mar |
Date Detail:
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Created Date: 2003-03-05 Completed Date: 2003-10-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: England |
Other Details:
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Languages: eng Pagination: 859-62 Citation Subset: IM |
Affiliation:
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Laboratoire de Chimie BioOrganique et des Systèmes Moléculaire Vectoriels, Faculté des Sciences, 33 rue Louis Pasteur, 84000 Avignon, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antioxidants
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chemical synthesis*,
pharmacology* Apoptosis / drug effects Caspases / antagonists & inhibitors, classification Cell Survival / drug effects Cells, Cultured Glycosylation Hydrogen Peroxide / chemistry Neurodegenerative Diseases / drug therapy Neurons / cytology Neuroprotective Agents / chemical synthesis, pharmacology Nitrogen Oxides / chemical synthesis*, chemistry, pharmacology* Oxidation-Reduction Spin Trapping |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Neuroprotective Agents; 0/Nitrogen Oxides; 0/nitrones; 7722-84-1/Hydrogen Peroxide; EC 3.4.22.-/Caspases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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