| Synthesis of new conformationally constrained pentasaccharides as molecular probes to investigate the biological activity of heparin. | |
| | |
MedLine Citation:
|
PMID: 12765779 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We have synthesized three new antithrombin activating pentasaccharides displaying various sulfation patterns on the reducing end unit (H). We found that when L-iduronic acid stands in the 2S(0) conformation, the sulfate groups at positions 3 and 6 of the reducing end unit are practically devoid of influence on the activation of antithrombin. This suggests that the positive role of these sulfates is more related to their ability to shift the conformational equilibrium of L-iduronic acid towards 3S(0) than to directly interact with the protein. |
| | |
Authors:
|
Eugen Sisu; Sasmita Tripathy; Jean-M Mallet; Pierre-A Driguez; Jean-P Hérault; Philippe Sizun; Jean-M Herbert; Maurice Petitou; Pierre Sinay |
Related Documents
:
|
3115589 - The presence of chondroitin sulfate in parotid secretory granules and saliva of the rat. 15244449 - In vitro reconstitution of fibrillar collagen type i assemblies at reactive polymer sur... 1596919 - Proteoglycans in human burn hypertrophic scar from a patient with ehlers-danlos syndrome. 21110089 - Functions of chondroitin sulfate and heparan sulfate in the developing brain. 12201999 - Bone morphogenetic proteins-2, -12, and -13 modulate in vitro development of engineered... 2241979 - Myristoylation of heparan sulfate proteoglycan and proteins occurs post-translationally... 2506259 - Variations and comparisons in medium-depth chemical peeling. 17313149 - Simultaneous determination of catecholamines and amino acids by micellar electrokinetic... 3478019 - The effect of arginine on in-vitro acid production by the oral bacterium streptococcus ... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Biochimie Volume: 85 ISSN: 0300-9084 ISO Abbreviation: Biochimie Publication Date: 2003 Jan-Feb |
Date Detail:
|
Created Date: 2003-05-26 Completed Date: 2004-12-22 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 1264604 Medline TA: Biochimie Country: France |
Other Details:
|
Languages: eng Pagination: 91-9 Citation Subset: IM |
Affiliation:
|
Ecole Normale Supérieure, Département de Chimie Associé au CNRS, 24, rue Lhomond, 75231 Paris cedex 5, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Antithrombin III
/
chemistry,
metabolism Antithrombins / chemistry*, metabolism Binding Sites Carbohydrate Conformation Carbohydrate Sequence Glycoproteins / chemistry, metabolism Heparin / chemistry*, metabolism Iduronic Acid / chemistry, metabolism Molecular Probes Molecular Sequence Data Oligosaccharides / chemical synthesis*, metabolism Structure-Activity Relationship Sulfates / chemistry, metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Antithrombins; 0/Glycoproteins; 0/Molecular Probes; 0/Oligosaccharides; 0/Sulfates; 3402-98-0/Iduronic Acid; 9000-94-6/Antithrombin III; 9005-49-6/Heparin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: 1976-1983, a critical period in the history of heparin: the discovery of the antithrombin binding si...
Next Document: In acute inflammation, the chondroitin-4 sulphate carried by bikunin is not only longer, it is also ...