Document Detail


Synthesis of new 2,5-disubstituted-1,3,4-thiadiazoles and preliminary evaluation of anticonvulsant and antimicrobial activities.
MedLine Citation:
PMID:  12110309     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two new series of 2,5-disubstituted-1,3,4-thiadiazoles were synthesized for their possible anticonvulsant, antibacterial and antifungal activities. The degree of protection afforded by these compounds at a dose of 100mg/kg i.p. against pentylenetetrazole-induced convulsions in mice ranged from 0 to 90%. Among these compounds, 2a (90%) and 2g (70%) showed maximum protection. Antimicrobial tests showed that the MIC value of 3j against Pseudomanas aeruginosa was equal to that of penicillin.
Authors:
Hatice N Dogan; Arzu Duran; Sevim Rollas; Göksel Sener; Meral K Uysal; Dumrul Gülen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bioorganic & medicinal chemistry     Volume:  10     ISSN:  0968-0896     ISO Abbreviation:  Bioorg. Med. Chem.     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-07-11     Completed Date:  2003-07-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9413298     Medline TA:  Bioorg Med Chem     Country:  England    
Other Details:
Languages:  eng     Pagination:  2893-8     Citation Subset:  IM    
Affiliation:
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Marmara University, 81010 Haydarpasa, Istanbul, Turkey. nesedogan19@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Bacterial Agents / administration & dosage,  chemical synthesis*,  pharmacology
Anticonvulsants / administration & dosage,  chemical synthesis*,  pharmacology
Drug Evaluation, Preclinical
Mice
Mice, Inbred BALB C
Microbial Sensitivity Tests
Pseudomonas aeruginosa / drug effects
Seizures / drug therapy
Thiadiazoles / administration & dosage,  chemical synthesis*,  pharmacology
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Anticonvulsants; 0/Thiadiazoles

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