Document Detail


Synthesis and neuropharmacology of cyclobutanecarboxylic acid derivatives.
MedLine Citation:
PMID:  1261667     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Urea, hydrazide and amide derivatives of cyclobutanecarboxylic acid have been examined for central nervous systems depressant properties, potentiation of barbiturate induced sleep, myorelaxant, antitremorine and anticonvulsant activity. The urea derivatives have central nervous system depressant qualities while the hydrazines and heterocyclic amides are either inactive or have central nervous system excitatory properties. N,N'-o-methoxybenzylidenebiscyclobutanecarboxamide and 1,3-dicyclo-butanecarbonyl-2-thiourea are myorelaxant; 1-cyclobutanecarbonyl-3-allylurea antagonizes Metrazol induced convulsions; 1,3-dicyclobutanecarbonyl-2-thiourea and N-cyclobutanecarbonyl morpholine antagonizes tremorine induced tremors.
Authors:
K A Zirvi; C H Jarboe
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Il Farmaco; edizione scientifica     Volume:  31     ISSN:  0430-0920     ISO Abbreviation:  Farmaco Sci     Publication Date:  1976 Feb 
Date Detail:
Created Date:  1976-07-06     Completed Date:  1976-07-06     Revised Date:  2009-06-05    
Medline Journal Info:
Nlm Unique ID:  0370716     Medline TA:  Farmaco Sci     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  152-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Anticonvulsants / chemical synthesis
Barbiturates / pharmacology
Carboxylic Acids / chemical synthesis,  pharmacology*
Central Nervous System / drug effects*
Cyclobutanes / chemical synthesis,  pharmacology*
Drug Synergism
Female
Mice
Muscle Relaxants, Central / chemical synthesis
Sleep / drug effects
Chemical
Reg. No./Substance:
0/Anticonvulsants; 0/Barbiturates; 0/Carboxylic Acids; 0/Cyclobutanes; 0/Muscle Relaxants, Central

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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