Document Detail


Synthesis of a nanostructured star block copolymer with a cyclotriphosphazene core.
MedLine Citation:
PMID:  17252786     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An amphiphilic star block copolymer of poly(L-lactic acid)-b-poly(ethylene glycol) (PLLA-b-PEG) was synthesized using a hexachlorocyclotriphosphazene ring (N3P3Cl6) as a core. N3P3(OC6H4-p-CHO)6 was prepared by the reaction between the hexachlorocyclotriphosphazene core and 4-hydroxybenzaldehyde sodium salt. N3P3(OC6H4-p-CH2OH)6 was then obtained by reduction of N3P3(OC6H4-p-CHO)6. N3P3(OC6H4-p-CH2OH)6 was used as an initiator to obtain a PLLA-grafted star branched polymer by polymerizing lactide, which was then treated with succinic acid to produce a carboxylated PLLA-grafted star polymer. PEG blocks were attached to a carboxylated PLLA-grafted star polymer to produce an amphiphilic PLLA-b-PEG-grafted star block polymer by additional esterification with poly(ethylene glycol methyl ether).
Authors:
Jae Kook Han; Sung Tae Kim; Hyun Jung Kim; Yong Ku Kwon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of nanoscience and nanotechnology     Volume:  6     ISSN:  1533-4880     ISO Abbreviation:  J Nanosci Nanotechnol     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2007-01-26     Completed Date:  2007-03-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101088195     Medline TA:  J Nanosci Nanotechnol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3446-9     Citation Subset:  IM    
Affiliation:
Department of Polymer Science and Engineering, Inha University, Incheon 402-751, Korea.
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MeSH Terms
Descriptor/Qualifier:
Biocompatible Materials
Drug Carriers / chemistry
Hexanoic Acids / chemistry
Lactic Acid / chemistry*
Macromolecular Substances
Magnetic Resonance Spectroscopy
Microscopy, Atomic Force
Microscopy, Electron, Scanning
Models, Chemical
Molecular Conformation
Nanoparticles / chemistry*
Nanotechnology / instrumentation,  methods*
Polyethylene Glycols / chemistry
Polyglycolic Acid / chemistry
Polymers / chemistry*
Temperature
Chemical
Reg. No./Substance:
0/Biocompatible Materials; 0/Drug Carriers; 0/Hexanoic Acids; 0/Macromolecular Substances; 0/Polyethylene Glycols; 0/Polymers; 26009-03-0/Polyglycolic Acid; 26100-51-6/poly(lactic acid); 50-21-5/Lactic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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