Document Detail


Synthesis and metal-binding properties of chelating fluorescein derivatives.
MedLine Citation:
PMID:  12790526     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
[reaction: see text] Two routes to highly functionalized metal-chelating fluorescein derivatives have been pursued. Compound 3 is partially quenched by a variety of first-row transition metal ions in aqueous solution, with EC(50) values ranging from 0.4 to 60 microM. Compounds of this type may find application in biological sensing.
Authors:
Matthew A Clark; Kathryn Duffy; Jyoti Tibrewala; Stephen J Lippard
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Organic letters     Volume:  5     ISSN:  1523-7060     ISO Abbreviation:  Org. Lett.     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-06-06     Completed Date:  2003-11-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  100890393     Medline TA:  Org Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2051-4     Citation Subset:  IM    
Affiliation:
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
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MeSH Terms
Descriptor/Qualifier:
Chelating Agents / chemistry*
Fluoresceins / chemistry*
Ligands
Metals, Heavy / chemistry*
Spectrometry, Fluorescence
Grant Support
ID/Acronym/Agency:
GM-65519/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Chelating Agents; 0/Fluoresceins; 0/Ligands; 0/Metals, Heavy

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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