Document Detail


Synthesis of lipidic magnetic nanoparticles for nucleic Acid delivery.
MedLine Citation:
PMID:  23070774     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Lipidic magnetic nanoparticles are a rapid and reliable magnet-guided nucleic acid delivery system, which we have named as "LipoMag" (Namiki et al., Nat. Nanotechnol 4:598-606, 2009). LipoMag is composed of a cationic lipid shell, an oleic acid binder, and an iron oxide nanocrystal core. Through the electrostatic force, positively charged LipoMag and negatively charged nucleic acid form complexes, termed "mag-lipoplex." Under a magnetic field, LipoMag bearing nucleic acid can be controllably accumulated in target cells. Here we describe the procedure for the preparation of LipoMag which can be used for the transfection of nucleic acids, such as plasmid DNA and small interfering RNA.
Authors:
Yoshihisa Namiki
Related Documents :
24563034 - Analysis of the loss in heat and acid resistance during germination of spores of bacill...
9657764 - Regulation and processing of a precursor form of eosinophil granule major basic protein...
1915744 - Schistosoma mansoni: eggshell formation is regulated by ph and calcium.
4656594 - The effect of anoxia on cerebral acid hydrolases in the five-day-old rat.
23524104 - Mesoporous silica (mcm-41)-fe2o3 as a novel magnetic nanosensor for determination of tr...
17245744 - Novel cholic acid functionalized star oligo/poly(dl-lactide)s for biomedical applications.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Methods in molecular biology (Clifton, N.J.)     Volume:  948     ISSN:  1940-6029     ISO Abbreviation:  Methods Mol. Biol.     Publication Date:  2013  
Date Detail:
Created Date:  2012-10-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9214969     Medline TA:  Methods Mol Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  243-50     Citation Subset:  IM    
Affiliation:
Institute of Clinical Medicine and Research, The Jikei University School of Medicine, Kashiwa, Japan, cancer_gene_therapy@ybb.ne.jp.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Magnetic and acoustically active microbubbles loaded with nucleic acids for gene delivery.
Next Document:  Lipopeptide Delivery of siRNA to the Central Nervous System.