| Synthesis of lipidic magnetic nanoparticles for nucleic Acid delivery. | |
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MedLine Citation:
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PMID: 23070774 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Lipidic magnetic nanoparticles are a rapid and reliable magnet-guided nucleic acid delivery system, which we have named as "LipoMag" (Namiki et al., Nat. Nanotechnol 4:598-606, 2009). LipoMag is composed of a cationic lipid shell, an oleic acid binder, and an iron oxide nanocrystal core. Through the electrostatic force, positively charged LipoMag and negatively charged nucleic acid form complexes, termed "mag-lipoplex." Under a magnetic field, LipoMag bearing nucleic acid can be controllably accumulated in target cells. Here we describe the procedure for the preparation of LipoMag which can be used for the transfection of nucleic acids, such as plasmid DNA and small interfering RNA. |
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Authors:
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Yoshihisa Namiki |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Methods in molecular biology (Clifton, N.J.) Volume: 948 ISSN: 1940-6029 ISO Abbreviation: Methods Mol. Biol. Publication Date: 2013 |
Date Detail:
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Created Date: 2012-10-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9214969 Medline TA: Methods Mol Biol Country: United States |
Other Details:
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Languages: eng Pagination: 243-50 Citation Subset: IM |
Affiliation:
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Institute of Clinical Medicine and Research, The Jikei University School of Medicine, Kashiwa, Japan, cancer_gene_therapy@ybb.ne.jp. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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