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Synthesis of lipidic magnetic nanoparticles for nucleic Acid delivery.
MedLine Citation:
PMID:  23070774     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Lipidic magnetic nanoparticles are a rapid and reliable magnet-guided nucleic acid delivery system, which we have named as "LipoMag" (Namiki et al., Nat. Nanotechnol 4:598-606, 2009). LipoMag is composed of a cationic lipid shell, an oleic acid binder, and an iron oxide nanocrystal core. Through the electrostatic force, positively charged LipoMag and negatively charged nucleic acid form complexes, termed "mag-lipoplex." Under a magnetic field, LipoMag bearing nucleic acid can be controllably accumulated in target cells. Here we describe the procedure for the preparation of LipoMag which can be used for the transfection of nucleic acids, such as plasmid DNA and small interfering RNA.
Authors:
Yoshihisa Namiki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Methods in molecular biology (Clifton, N.J.)     Volume:  948     ISSN:  1940-6029     ISO Abbreviation:  Methods Mol. Biol.     Publication Date:  2013  
Date Detail:
Created Date:  2012-10-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9214969     Medline TA:  Methods Mol Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  243-50     Citation Subset:  IM    
Affiliation:
Institute of Clinical Medicine and Research, The Jikei University School of Medicine, Kashiwa, Japan, cancer_gene_therapy@ybb.ne.jp.
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