Document Detail


Synthesis and lectin binding ability of glycosamino acid-calixarenes exposing GlcNAc clusters.
MedLine Citation:
PMID:  15524433     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Novel calix[4 or 8]arene-based glycoconjugates exposing terminal N-acetyl-D-glucosamine clusters have been synthesized using amino acid-calixarenes as building blocks. The obtained glycosamino acid-calixarenes 9b-14b have lectin-binding ability and amplified inhibitory effects on erythrocyte agglutination induced by wheat germ (Triticum vulgaris) agglutinin (WGA). The inhibitory ability is dependent on the presence of the spacer and on the shape and rigidity of the calixarene skeleton.
Authors:
Grazia M L Consoli; Francesca Cunsolo; Corrada Geraci; Valentina Sgarlata
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Organic letters     Volume:  6     ISSN:  1523-7060     ISO Abbreviation:  Org. Lett.     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-11-04     Completed Date:  2006-02-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100890393     Medline TA:  Org Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4163-6     Citation Subset:  IM    
Affiliation:
Istituto di Chimica Biomolecolare, Sezione di Catania CNR, Via del Santuario 110, I-95028 Valverde (CT), Italy.
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MeSH Terms
Descriptor/Qualifier:
Acetylglucosamine / chemistry*
Calixarenes / chemical synthesis*,  chemistry
Lectins / metabolism*
Molecular Structure
Protein Binding
Chemical
Reg. No./Substance:
0/Lectins; 130036-26-9/Calixarenes; 7512-17-6/Acetylglucosamine

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