| Synthesis and lectin binding ability of glycosamino acid-calixarenes exposing GlcNAc clusters. | |
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MedLine Citation:
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PMID: 15524433 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Novel calix[4 or 8]arene-based glycoconjugates exposing terminal N-acetyl-D-glucosamine clusters have been synthesized using amino acid-calixarenes as building blocks. The obtained glycosamino acid-calixarenes 9b-14b have lectin-binding ability and amplified inhibitory effects on erythrocyte agglutination induced by wheat germ (Triticum vulgaris) agglutinin (WGA). The inhibitory ability is dependent on the presence of the spacer and on the shape and rigidity of the calixarene skeleton. |
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Authors:
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Grazia M L Consoli; Francesca Cunsolo; Corrada Geraci; Valentina Sgarlata |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Organic letters Volume: 6 ISSN: 1523-7060 ISO Abbreviation: Org. Lett. Publication Date: 2004 Nov |
Date Detail:
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Created Date: 2004-11-04 Completed Date: 2006-02-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100890393 Medline TA: Org Lett Country: United States |
Other Details:
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Languages: eng Pagination: 4163-6 Citation Subset: IM |
Affiliation:
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Istituto di Chimica Biomolecolare, Sezione di Catania CNR, Via del Santuario 110, I-95028 Valverde (CT), Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetylglucosamine
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chemistry* Calixarenes / chemical synthesis*, chemistry Lectins / metabolism* Molecular Structure Protein Binding |
| Chemical | |
Reg. No./Substance:
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0/Lectins; 130036-26-9/Calixarenes; 7512-17-6/Acetylglucosamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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