| Synthesis, in vitro, reactivity, and identification of 6-phenyl-3-hexen-2-one in human urine after kava-kava (Piper methysticum) ingestion. | |
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MedLine Citation:
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PMID: 15729622 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study describes the synthesis of 6 -phenyl-3-hexen-2-one, a proposed metabolite of kava-kava (kava, 'Awa, Yaqona, Piper methysticum Forst.), its reactivity with glutathione in vitro, and its isolation and identification, as its mercapturic acid adduct using LC/MS/MS, in the urine of two human subjects following their ingestion of kava. A possible metabolic pathway for the formation of this metabolite and its possible role in hepatotoxicity are also discussed. |
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Authors:
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Lihong Zou; Martha R Harkey; Gary L Henderson |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Planta medica Volume: 71 ISSN: 0032-0943 ISO Abbreviation: Planta Med. Publication Date: 2005 Feb |
Date Detail:
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Created Date: 2005-02-24 Completed Date: 2005-04-21 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0066751 Medline TA: Planta Med Country: Germany |
Other Details:
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Languages: eng Pagination: 142-6 Citation Subset: IM |
Affiliation:
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Department of Medical Pharmacology and Toxicology, School of Medicine, University of California, Davis, CA 95616, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Beverages* Drug-Induced Liver Injury / etiology Humans Kava* Lactones / urine* Liver / drug effects, metabolism Phytotherapy* Plant Extracts / administration & dosage, pharmacology*, toxicity Plant Roots |
| Grant Support | |
ID/Acronym/Agency:
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R01 AT000636/AT/NCCAM NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Lactones; 0/Plant Extracts |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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