Document Detail


Synthesis, in vitro, reactivity, and identification of 6-phenyl-3-hexen-2-one in human urine after kava-kava (Piper methysticum) ingestion.
MedLine Citation:
PMID:  15729622     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study describes the synthesis of 6 -phenyl-3-hexen-2-one, a proposed metabolite of kava-kava (kava, 'Awa, Yaqona, Piper methysticum Forst.), its reactivity with glutathione in vitro, and its isolation and identification, as its mercapturic acid adduct using LC/MS/MS, in the urine of two human subjects following their ingestion of kava. A possible metabolic pathway for the formation of this metabolite and its possible role in hepatotoxicity are also discussed.
Authors:
Lihong Zou; Martha R Harkey; Gary L Henderson
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Planta medica     Volume:  71     ISSN:  0032-0943     ISO Abbreviation:  Planta Med.     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-02-24     Completed Date:  2005-04-21     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0066751     Medline TA:  Planta Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  142-6     Citation Subset:  IM    
Affiliation:
Department of Medical Pharmacology and Toxicology, School of Medicine, University of California, Davis, CA 95616, USA.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Beverages*
Drug-Induced Liver Injury / etiology
Humans
Kava*
Lactones / urine*
Liver / drug effects,  metabolism
Phytotherapy*
Plant Extracts / administration & dosage,  pharmacology*,  toxicity
Plant Roots
Grant Support
ID/Acronym/Agency:
R01 AT000636/AT/NCCAM NIH HHS
Chemical
Reg. No./Substance:
0/Lactones; 0/Plant Extracts

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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