| Synthesis and in-vitro inotropic evaluation of 2-(4-substitutedbenzyl-1,4-diazepan-1-yl)-N-(4,5-dihydro-1-phenyl-[1,2,4]triazolo[4,3-a]quinolin-7-yl)acetamides. | |
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MedLine Citation:
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PMID: 21110340 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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We describe the synthesis and positive inotropic evaluation of a series of 2-(4-substitutedbenzyl-1,4-diazepan-1-yl)-N-(4,5-dihydro-1-phenyl-[1,2,4]triazolo[4,3-a]quinolin-7-yl)acetamides by measuring left atrial stroke volume in preparations of isolated rabbit-heart. Several compounds were developed from, and showed favorable activities compared with the standard drug milrinone. Compound 5o was the most potent with an increased stroke volume of 9.17 ± 0.14% (milrinone 2.47 ± 0.08%) at 3 × 10(-5) M in our in-vitro study. The chronotropic effects of those compounds having inotropic effects were also evaluated. |
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Authors:
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Sheng-Ming Jiang; Bai-Jun Ye; Xue-Kun Liu; Tian-Yi Zhang; Xun Cui; Hu-Ri Piao |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archiv der Pharmazie Volume: 343 ISSN: 1521-4184 ISO Abbreviation: Arch. Pharm. (Weinheim) Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0330167 Medline TA: Arch Pharm (Weinheim) Country: Germany |
Other Details:
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Languages: eng Pagination: 700-5 Citation Subset: IM |
Affiliation:
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Key Laboratory of Natural Resources of Changbai Mountain & Functional Molecules, Ministry of Education; Yanbian University College of Pharmacy, Yanji, P.R. China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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