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Synthesis and in-vitro inotropic evaluation of 2-(4-substitutedbenzyl-1,4-diazepan-1-yl)-N-(4,5-dihydro-1-phenyl-[1,2,4]triazolo[4,3-a]quinolin-7-yl)acetamides.
MedLine Citation:
PMID:  21110340     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
We describe the synthesis and positive inotropic evaluation of a series of 2-(4-substitutedbenzyl-1,4-diazepan-1-yl)-N-(4,5-dihydro-1-phenyl-[1,2,4]triazolo[4,3-a]quinolin-7-yl)acetamides by measuring left atrial stroke volume in preparations of isolated rabbit-heart. Several compounds were developed from, and showed favorable activities compared with the standard drug milrinone. Compound 5o was the most potent with an increased stroke volume of 9.17 ± 0.14% (milrinone 2.47 ± 0.08%) at 3 × 10(-5) M in our in-vitro study. The chronotropic effects of those compounds having inotropic effects were also evaluated.
Authors:
Sheng-Ming Jiang; Bai-Jun Ye; Xue-Kun Liu; Tian-Yi Zhang; Xun Cui; Hu-Ri Piao
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archiv der Pharmazie     Volume:  343     ISSN:  1521-4184     ISO Abbreviation:  Arch. Pharm. (Weinheim)     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0330167     Medline TA:  Arch Pharm (Weinheim)     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  700-5     Citation Subset:  IM    
Affiliation:
Key Laboratory of Natural Resources of Changbai Mountain & Functional Molecules, Ministry of Education; Yanbian University College of Pharmacy, Yanji, P.R. China.
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