Document Detail

Synthesis and in vitro evaluation of ambrisentan analogues as potential endothelin receptor antagonists.
MedLine Citation:
PMID:  21652209     Owner:  NLM     Status:  Publisher    
A series of novel 2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3,3-diphenyl butyric acid derivatives were synthesized and evaluated for their antagonistic activity for endothelin-1-induced contraction in rabbit aorta. Within this series of compounds, 2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-cyano-3,3-diphenylpropionic acid (4) displays comparable potency with ambrisentan (1), and warrants further investigation.
Jun Xia; Jianfei Song; Le Zhen; Xiuling Zhang; Xiantao Lei; Lina Zheng; Qiujuan Wang; Hongbin Sun
Related Documents :
17291449 - Cholesterol depletion inhibits fatty acid uptake without affecting cd36 or caveolin-1 d...
22124279 - Evidence of aggregation induced emission enhancement and keto-enol-tautomerism in a gal...
18712899 - Evaluation of the pharmacokinetic effects of various linking group using the 111in-dota...
1033209 - Umbilical uptake of amino acids in the unstressed fetal lamb.
3880799 - Inhibition of nocardia asteroides by neutrophils.
1966929 - The activating effect of fatty acid on the mitochondrial uncoupling protein reconstitut...
15246439 - Characteristics of anaerobic ammonia removal by a mixed culture of hydrogen producing p...
15130609 - Discriminative power of an assay for automated in vitro screening of teratogens.
1956299 - Nucleotide sequence of the endoglucanase c gene (cenc) of cellulomonas fimi, its high-l...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-24
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  -     ISSN:  1464-3405     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-6-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
Center for Drug Discovery, College of Pharmacy, China Pharmaceutical University, 24 Tongjia Xiang, Nanjing 210009, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Rhamnetin production based on the rational design of the poplar O-methyltransferase enzyme and its b...
Next Document:  A concise synthesis and antimicrobial activities of 3-polyamino-23,24-bisnorcholanes as steroid-poly...