Document Detail


Synthesis and in vitro biocompatibility of injectable polyurethane foam scaffolds.
MedLine Citation:
PMID:  16771638     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The development of therapeutics for orthopedic clinical indications exploiting minimally invasive surgical techniques has substantial benefits, especially for treatment of fragility fractures in the distal radius of osteoporotics and vertebral compression fractures. We have designed six formulations of injectable polyurethane foams to address these clinical indications. The polyurethanes were prepared by mixing two liquid components and injecting the reactive liquid mixture into a mold where it hardens in situ. Porous polyurethane foams were synthesized from lysine methyl ester diisocyanate, a poly(epsilon-caprolactone-co-glycolide) triol, a tertiary amine catalyst, anionic and non-ionic stabilizers, and a fatty acid pore opener. The rise time of the foams varied from 8-20 min. The porosity was approximately 95% and the pores varied in size from 100-1000 microm. The polyurethane foams supported attachment of viable (>95%) MG-63 cells under dynamic seeding conditions. We anticipate compelling opportunities will be available as a consequence of the favorable biological and physical properties of the injectable polyurethane foams.
Authors:
Scott A Guelcher; Vishal Patel; Katie M Gallagher; Susan Connolly; Jonathan E Didier; John S Doctor; Jeffrey O Hollinger
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Tissue engineering     Volume:  12     ISSN:  1076-3279     ISO Abbreviation:  Tissue Eng.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-06-14     Completed Date:  2006-08-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9505538     Medline TA:  Tissue Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1247-59     Citation Subset:  IM    
Affiliation:
Department of Chemical Engineering, Vanderbilt University, Nashville, Tennessee 37235, USA. scott.guelcher@vanderbilt.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Bacterial Proteins / chemical synthesis*,  chemistry
Bone Substitutes / chemical synthesis*,  chemistry
Cell Line
Fractures, Compression / therapy
Humans
Lipase / chemical synthesis*,  chemistry
Materials Testing*
Osteoporosis / therapy
Porosity
Spinal Fractures / therapy
Grant Support
ID/Acronym/Agency:
R25 GM0066943/GM/NIGMS NIH HHS; T32EB00424/EB/NIBIB NIH HHS
Chemical
Reg. No./Substance:
0/Bacterial Proteins; 0/Bone Substitutes; EC 3.1.1.-/pueA protein, Pseudomonas chlororaphis; EC 3.1.1.3/Lipase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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